The San Francisco Giants host the Minnesota Twins on September 23, 2026. First pitch from Oracle Park is scheduled for 3:45 p.m. EDT. The game will be broadcast on MNNT.
The Twins are favored by -148 on the moneyline and by -1.5 on the run line. The Giants are +123 on the moneyline and +1.5 on the run line. The total is set at 7.5 runs.
Find our MLB picks and Twins vs Giants prediction below, as well as probable pitchers, weather report, and more.
Twins vs Giants Prediction
- Twins vs Giants Pick: Luke Keaschall Over 1.5 Hits (+178)
Our Twins vs Giants best bet is on Luke Keaschall to record over 1.5 hits. Make sure to find the best odds by checking our live MLB odds page and download the Action Network app for more picks and analysis!
Twins vs Giants Odds
| Twins Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +117 | 7.5 -119o / -101u | -148 |
| Giants Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -142 | 7.5 -119o / -101u | +123 |
- Twins vs Giants moneyline: Twins -148, Giants +123
- Twins vs Giants over/under: 7.5 (-119o / -101u)
- Twins vs Giants spread: Twins -1.5 (+117), Giants +1.5 (-142)
Twins vs Giants Probable Pitchers
| Connor Prielipp (LHP, MIN) | Stat | Cesar Perdomo (LHP, SFG) |
|---|---|---|
| 6-7 | W-L | 0-1 |
| 1.9 | fWAR (FanGraphs) | 0.0 |
| 4.94/3.99 | ERA / xERA | 3.72/4.92 |
| 3.76/3.91 | FIP / xFIP | 4.96/4.74 |
| 16.2% | K-BB% | 6.0% |
| 42.0% | GB% | 40.3% |
| .308 | BABIP | .311 |
| 103 | Stuff+ | 88 |
| 103 | Location+ | 104 |
Twins vs Giants MLB Betting Preview
The Minnesota Twins (74-84) head to Oracle Park on Wednesday afternoon to close out a three-game rubber match against the San Francisco Giants (65-93).
Minnesota comes into this series finale holding down third place in the AL Central, while San Francisco sits fourth in the NL West as both clubs wind down their regular season slates.
The Twins feature solid power production, ranking fifth in the American League with a team slugging percentage of .402, but they have sputtered on the road with a 34-46 away record.
Meanwhile, San Francisco carries a 37-40 mark on home turf. Long-ball vulnerability has plagued the Giants all year, as they hold an abysmal 34-67 record when surrendering at least one home run.
On the bump, Minnesota sends out Connor Prielipp (6-7, 4.94 ERA, 1.30 WHIP, 125 Ks). Prielipp delivers momentum into this outing after putting together a career-best performance against the Angels, where he pitched seven full innings and fanned eight batters.
San Francisco counters with rookie Cesar Perdomo (0-1, 3.72 ERA, 1.50 WHIP, 12 Ks). Perdomo makes his fifth career big-league appearance and fourth start as he continues to search for his first MLB victory.
Twins vs Giants Pick, Betting Analysis
There is tremendous value on Luke Keaschall in the props market for Wednesday's series finale.
Action PRO projects Keaschall for 1.61 hits against San Francisco, unlocking a clear 12% edge with his current prop line of over/under 1.5. This makes the Over an absolute slam dunk, earning a top-tier A grade in the rating systems.
Keaschall enters the contest locked in at the plate, collecting 13 hits over his last 40 at-bats (.325 average) alongside a double and a triple across his past 10 games.
Facing Perdomo—who carries a elevated 1.50 WHIP—gives Keaschall a favorable matchup to stay hot.
Securing this prop at lucrative plus-money prices delivers massive value.
Pick: Luke Keaschall Over 1.5 Hits (+178)
