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Red Sox vs Mariners Prediction, Pick, MLB Odds for Sunday, June 21

Red Sox vs Mariners Prediction, Pick, MLB Odds for Sunday, June 21 article feature image
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The Seattle Mariners host the Boston Red Sox on June 21, 2026. First pitch from T-Mobile Park is scheduled for 4:10 p.m. ET. The game will be broadcast on NESN.

The Mariners are favored by -144 on the moneyline and by -1.5 on the run line. The Red Sox are +122 on the moneyline and +1.5 on the run line. The total is set at 6.5 runs.

Find my MLB picks and Red Sox vs Mariners prediction below, as well as probable pitchers, weather report, and more.


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Red Sox vs Mariners Prediction

Red Sox vs Mariners Picks:

  • NRFI (-178)
  • F5 Under (-120)

Red Sox vs Mariners Odds

Red Sox Logo
Sunday, Jun 21
4:10 p.m. ET
NESN
Mariners Logo
Red Sox Odds
SpreadTotalMoneyline
+1.5
-200
6.5
-122o / -100u
+122
Mariners Odds
SpreadTotalMoneyline
-1.5
+164
6.5
-122o / -100u
-144
Odds via FanDuel. Get up-to-the-minute MLB odds here.
FanDuel Logo


Red Sox vs Mariners Probable Pitchers

Payton Tolle (LHP, BOS)StatLogan Gilbert (RHP, SEA)
3-4W-L5-4
1.7fWAR (FanGraphs)1.4
2.93 / 2.66ERA / xERA3.43 / 4.01
3.08 / 3.97FIP / xFIP3.79 / 3.67
18.6%K-BB%20.8%
34.4%GB%32.9%
.268BABIP.259
115Stuff+107
95Location+105

Red Sox vs Mariners MLB Betting Preview

The Red Sox and Mariners will duke it out on Sunday afternoon to finish off the last of a three-game set at T-Mobile Park in Seattle.

I’m very excited for this pitching matchup, with Payton Tolle facing off against Logan Gilbert.

In just his second season in the Major Leagues, Tolle has been brilliant, running a 2.93 ERA and 1.06 WHIP through 58 frames.

Like Tolle, Gilbert has also had a great start to the season, running a 3.43 ERA and 1.03 WHIP across 87 innings.


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Red Sox vs Mariners Pick, Betting Analysis

Given the elite form of both starting pitchers in Sunday afternoon’s contest, I think this is a great spot to back for there to be no runs scored in the first inning (NRFI) of the game.

As a secondary betting angle, I favor buying into that same starting-pitching duel narrative and thus will be wagering for the first five total to go under in what should be a very closely contested, low-scoring affair.

Picks:

  • NRFI (-178)
  • F5 Under (-120)

Red Sox vs Mariners Weather


Get the latest coverage on MLB Weather.
Author Profile
About the Author

Ryan graduated from Providence College in 2016 with Bachelor Degrees in Business Economics & Mathematics. It was at Providence where Ryan really first found his passion for sports betting. For a lifelong sports fan with a knack for statistical analysis, he was instantly drawn to the fundamentals of the industry, specifically how sports betting markets functioned and fluctuated. In what primarily started as a recreational hobby, Ryan began studying the ins-and-outs of sports betting markets on a daily basis. He took to Twitter (now X), where he amassed a following for writing a sports betting blog that provided statistical analysis behind his wagers. In spite of seeking employment opportunities elsewhere post graduation, Ryan continued to follow his passion for the statistical analysis of sports betting wagers, eventually deciding to pursue a career in the sports betting industry.

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