The Chicago White Sox host the Chicago Cubs on May 17, 2026. First pitch from Rate Field is scheduled for 2:10 p.m. EDT. The game will be broadcast on CHSN.
The Cubs are favored by -142 on the moneyline and by -1.5 on the run line. The White Sox are +120 on the moneyline and +1.5 on the run line. The total is set at 8.5 runs.
Find my MLB picks and Cubs vs White Sox prediction below, as well as probable pitchers, weather report, and more.
Cubs vs White Sox Prediction
- Cubs vs White Sox Pick: Pete Crow-Armstrong Over 1.5 Hits + Runs + RBIs
My Cubs vs White Sox best bet is on PCA's HRR prop. Make sure to find the best odds by checking our live MLB odds page.
Cubs vs White Sox Odds
| Cubs Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +120 | 8.5 102o / -124u | -142 |
| White Sox Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -144 | 8.5 102o / -124u | +120 |
Cubs vs White Sox Probable Pitchers
| Colin Rea (RHP, CHC) | Stat | Erick Fedde (RHP, CHW) |
|---|---|---|
| 4-2 | W-L | 0-4 |
| 0.3 | fWAR (FanGraphs) | -0.3 |
| 4.68 / 5.33 | ERA / xERA | 3.77 / 4.15 |
| 4.23 / 3.78 | FIP / xFIP | 6.03 / 4.97 |
| 12.4% | K-BB% | 6.8% |
| 50.4% | GB% | 39.6% |
| .315 | BABIP | .208 |
| 94 | Stuff+ | 90 |
| 102 | Location+ | 106 |
Cubs vs White Sox MLB Betting Preview
I love rivalry weekend. I appreciate that the Cubs and White Sox are duking it out for Chicago supremacy.
Erick Fedde started out hot, but he’s since cooled off, allowing six earned runs over his past two outings, spread out across 12 hits and five homers in less than 10 frames.
Despite relying heavily on a sinker and slider, Fedde allows a ton of hard contact, especially against left-handed hitters.
Cubs vs White Sox Pick, Betting Analysis
Thus, I plan to fade Fedde against a lefty.
Pete Crow-Armstrong started slow, but he’s starting to round into form. And, historically, this is a good matchup for him — across five head-to-head plate appearances, Crow-Armstrong has two hits against Fedde.
PCA has a unique combination of speed and power — he bashed 31 homers and swiped 35 bags last season. And while he’s often prone to strikeouts, Fedde is not exactly a strikeout pitcher, giving Crow-Armstrong the edge in this head-to-head matchup.
Pick: Pete Crow-Armstrong Over 1.5 Hits + Runs + RBIs
