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Cubs vs Dodgers Prediction, Pick, MLB Odds for Saturday, April 25

Cubs vs Dodgers Prediction, Pick, MLB Odds for Saturday, April 25 article feature image
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Jonathan Hui-Imagn Images. Pictured: Roki Sasaki

The Los Angeles Dodgers host the Chicago Cubs on April 25, 2026. First pitch from UNIQLO Field at Dodger Stadium is scheduled for 7:15 p.m. EDT. The game will be broadcast on FOX.

The Dodgers are favored by -156 on the moneyline and by -1.5 on the run line. The Cubs are +132 on the moneyline and +1.5 on the run line. The total is set at 9 runs.

Find my MLB picks and Cubs vs Dodgers prediction below, as well as probable pitchers, weather report, and more.


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Cubs vs Dodgers Prediction

  • Cubs vs Dodgers Pick: Roki Sasaki Under 15.5 Outs (-170)

My Cubs vs Dodgers best bet is Roki Sasaki Under 15.5 Outs. Make sure to find the best odds by checking our live MLB odds page.


Cubs vs Dodgers Odds

Cubs Logo
Friday, Apr 24
10:15 p.m. ET
Apple TV+
Dodgers Logo
Cubs Odds
SpreadTotalMoneyline
+1.5
-162
9
-108o / -112u
+132
Dodgers Odds
SpreadTotalMoneyline
-1.5
+134
9
-108o / -112u
-156
Odds via FanDuel. Get up-to-the-minute MLB odds here.
FanDuel Logo
  • Cubs vs Dodgers moneyline: Cubs +132, Dodgers -156
  • Cubs vs Dodgers over/under: 9 (-108o / -112u)
  • Cubs vs Dodgers spread: Cubs +1.5 (-162), Dodgers -1.5 (+134)

Cubs vs Dodgers Polymarket Odds

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Cubs vs Dodgers Probable Pitchers

Colin Rea, CHCStatRoki Sasaki, LAD
3-0W-L0-2
0.4fWAR (FanGraphs)-0.2
3.00 / 3.38ERA / xERA6.11 / 5.67
3.30 / 3.58FIP / xFIP6.36 / 5.19
15.5%K-BB%5.9%
52.9%GB%40.7%
.261BABIP.333
95Stuff+99
102Location+88

Cubs vs Dodgers MLB Betting Preview

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Chicago Cubs Betting Preview: Somehow Red Hot

The Cubs are on fire right now. They just extended their win streak to 10 games after beating the Dodgers on Friday night and will hope to keep it going throughout the weekend.

They are achieving this despite a battered pitching staff and a sputtering Pete Crow-Armstrong. Cade Horton is out for the season, while all of their right-handed, high-leverage relievers, including closer Daniel Palencia, are on the Injured List.

They even lost interim closer Caleb Thielbar for the next two weeks due to a recent strained hamstring. Luckily, offseason signees Phil Maton and Hunter Harvey are on the mend and could join the team in the coming weeks.

The aforementioned Crow-Armstrong is hitting better since his demotion to the bottom of the order, yet he still has just one home run on the season. He will be better than a 78 wRC+ as the season progresses, but there are valid doubts about whether he could replicate his MVP-caliber first half of the 2025 season.

The good news is that there is more to celebrate than diminish on this Cubs roster. Aside from PCA and Michael Busch (who is heating up), every other regular hitter in this lineup has at least a 100 wRC+.

Furthermore, Nico Hoerner, Ian Happ, Seiya Suzuki, Moises Ballasteros, and Carson Kelly have at least a 140 wRC+ each through 28 games.

The offense is carrying a heavy load, but credit is due to starters like Shota Imanaga, Edward Cabrera, and Colin Rea. Each has pulled their weight thus far, while Imanaga specifically looks like Cy Young caliber SP again.

This Cubs roster could be formidable throughout the year if the bullpen stays healthy and Justin Steele looks like himself during his midseason return.

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Los Angeles Dodgers Betting Preview: Slumped Over

Both the Cubs and Dodgers have a 17-9 record, yet are going in separate directions. The Cubs are ascending, while the Dodgers have slumped throughout the past week.

The Dodgers have lost five of their past seven games, with series losses to the lowly Colorado Rockies and their division rivals, the San Francisco Giants. What is most concerning is their lack of offense in recent matches. This high-profile offense has averaged two runs in its past four games!

The offense would be better if they could play their best hitters every day, but the lack of versatility between Will Smith and Dalton Rushing makes their presence in the lineup difficult to maneuver. Shohei Ohtani is the permanent DH, forcing the rest of the team to play a position daily.

This offense will not tread water for long. They are just streaky, and nothing displays it better than their series in Coors last weekend, with 12 runs on Monday, then four total in the San Francisco series between Tuesday and Thursday.

Nevertheless, these are first-world problems for the best roster in baseball. They have reinforcements coming on offense in the form of perennial all-star Mookie Betts (oblqiue), along with the rotation when Blake Snell returns. Snell is currently ramping up in the minor leagues, while Betts began his hitting progression this week.


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Cubs vs Dodgers Pick, Betting Analysis

Until Snell returns, the Dodgers will continue rolling out their "prize" from last year's offseason, Roki Sasaki. On most teams, Sasaki's failures would not be tolerated in the rotation this long, but the Dodgers have the luxury of patience.

Sasaki's season thus far is a disaster. He has completed five full innings in just one game. However, he has also not pitched fewer than four innings in any start. The Dodgers are allowing him an ample opportunity to show them that he belongs in the rotation, but his clock is ticking.

Through 17 2/3 innings this season, Sasaki has a 6.11 ERA, 5,68 xERA, 5.17 xFIP, and a 5.07 SIERA. While his ERA is slightly worse than his peripheral stats, any number above 5.00 for a pitcher is horrendous.

Sasaki's walk rate ranks 10th-worst among all SP with at least 10 innings pitched, while his WHIP ranks eighth-worst. He is not a Dodgers-quality starter, nor would he start regularly on most teams (bottom-feeders like the Nationals would welcome him).

The only case for Sasaki pitching deep, beyond a lucky outing, is the Dodgers being stretched thin with starters in case he struggles. Justin Wrobleski would be the obvious "long man" if every SP were at full strength, but their utilization of a six-man rotation makes that unlikely.

Regardless, with Sasaki's stats thus far, the Chicago win blowing out, and the Cubs' offense ranking seventh in team wRC+ and fifth in walk rate against right-handed pitchers, do not expect him to pitch into the sixth inning.

This betting line is far more valuable than it appears. Multiple units are worth dropping on Sasaki's continued disappointment.

Pick: Roki Sasaki Under 15.5 Outs (-170)


Cubs vs Dodgers Weather


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Kevork MahserejianVerified Action Expert

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