The Minnesota Twins host the Chicago White Sox on September 3, 2025. First pitch from Target Field is scheduled for 7:40 p.m. EDT; the game will be broadcast on MNNT.
Find my MLB betting preview and White Sox vs Twins prediction below, as well as probable pitchers, betting trends, injury reports and more.
My White Sox vs Twins Prediction
- White Sox vs Twins picks: Zebby Matthews Over 5.5 Strikeouts
My White Sox vs Twins best bet is for Zebby Matthews to notch Over 5.5 Strikeouts. Make sure to find the best odds by checking our live MLB odds page.
White Sox vs Twins Odds
| White Sox Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 +114 | 8.5 -115o / -105u | +154 |
| Twins Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 -136 | 8.5 -115o / -105u | -184 |
Alex Kolodziej’s White Sox vs Twins Prediction, Betting Analysis
For Wednesday’s MLB slate, one of the standout betting picks from PRO Projections is backing Twins starter Zebby Matthews to record over 5.5 strikeouts against the White Sox. Our proprietary model, which leverages expert analysis, player projections, and betting market data, has arrived at a slightly higher — and more balanced — expected strikeout total of 6.1 for Matthews in this matchup.
Matthews faces a White Sox lineup that is well known for its high strikeout rates, especially on the road. The White Sox average 7.58 strikeouts per game, but that number jumps to 9.09 when playing away from home, signaling a favorable situation for Matthews to rack up strikeouts. While Matthews has failed to reach six strikeouts in back-to-back outings, he showcased strong strikeout numbers in his previous three games with totals of six, nine, and six, respectively.
Adding to the edge, Target Field, the Twins’ home ballpark, is ranked as the fifth-best stadium for pitcher strikeouts, according to Statcast data. This environment should further help Matthews increase his strikeout count. Although Matthews struggled in his last appearance against the Sox, giving up eight hits, four runs, and only striking out three batters over 4 2/3 innings, PRO Projections expect a bounce-back performance this time around.
Given these factors, betting on Matthews to exceed 5.5 strikeouts offers a data-driven value play for Wednesday night.
Pick: Zebby Matthews Over 5.5 Strikeouts
White Sox vs Twins Weather
