The Houston Astros host the Cleveland Guardians on June 21, 2026. First pitch from Daikin Park is scheduled for 2:10 p.m. ET. The game will be broadcast on CLEG.
The Astros are favored by -136 on the moneyline and by -1.5 on the run line. The Guardians are +113 on the moneyline and +1.5 on the run line. The total is set at 8.5 runs.
Find my MLB picks and Guardians vs Astros prediction below, as well as probable pitchers, weather report, and more.
Guardians vs Astros Prediction
- Guardians vs Astros Pick: Christian Walker Over 1.5 HRR (-121)
My Guardians vs Astros best bet is on Christian Walker recording two or more hits, runs and runs batted-in combined. Make sure to find the best odds by checking our live MLB odds page.
Guardians vs Astros Odds
| Guardians Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -181 | 8.5 -119o / -102u | +113 |
| Astros Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +149 | 8.5 -119o / -102u | -136 |
- Guardians vs Astros moneyline: Guardians +113, Astros -136
- Guardians vs Astros over/under: 8.5 (-119o / -102u)
- Guardians vs Astros spread: Guardians +1.5 (-181), Astros -1.5 (+149)
Guardians vs Astros Probable Pitchers
| Slade Cecconi (RHP, CLE) | Stat | Kai-Wei Teng (RHP, HOU) |
|---|---|---|
| 3-5 | W-L | 3-6 |
| 0.8 | fWAR (FanGraphs) | 0.1 |
| 4.60 / 4.40 | ERA / xERA | 4.31 / 4.42 |
| 4.34 / 4.13 | FIP / xFIP | 4.88 / 4.11 |
| 11.8% | K-BB% | 13.6% |
| 47.1% | GB% | 43.1% |
| .316 | BABIP | .279 |
| 93 | Stuff+ | 97 |
| 102 | Location+ | 92 |
Guardians vs Astros MLB Betting Preview
The Guardians and Astros will duke it out on Sunday afternoon as they close a three-game set at Daikin Park in Houston. Kai-Wei Teng will start for Houston, while Slade Cecconi will take the mound for the visiting Guardians.
Both starting pitchers have struggled this season, each posting ERA’s north of 4.30. So, I think this could be a good game to target some player props.
I’d rather look toward Houston hitters, given Teng has flashed some really solid stuff this season, while Cecconi has been downright atrocious (78 IP, 4.60 ERA, 1.40 WHIP)
Cecconi has made 38 starts in the AL over the past year and a half, so he’s matched up with many of Houston’s hitters on several occasions.
Guardians vs Astros Pick, Betting Analysis
One guy who has taken advantage of Cecconi is Christian Walker, who is 2-for-3 against Cleveland’s righty, including a two-run home run.
Cecconi mainly relies on a mid-90s four-seam fastball (29.4% usage, .354 xwOBA allowed, 18.6% whiff), alongside a cutter and a sinker. Ultimately, he’s been vulnerable to damage against pull-heavy right-handed power bats.
Walker is very disciplined at the plate and crushes right-handed fastballs, so I’m banking on him to have a big day in the batter’s box.
Pick: Christian Walker Over 1.5 HRR (-121, DraftKings)
