The Seattle Mariners host the Houston Astros on September 23, 2026. First pitch from T-Mobile Park is scheduled for 10:10 p.m. EDT. The game will be broadcast on ESPN.
The Mariners are favored by -125 on the moneyline and by -1.5 on the run line. The Astros are +105 on the moneyline and +1.5 on the run line. The total is set at 7.5 runs.
Find my MLB picks and Astros vs Mariners prediction below, as well as probable pitchers, weather report, and more.
Astros vs Mariners Prediction
- Astros vs Mariners Pick: Jeremy Pena Over 1.5 Total Bases (+150)
My Astros vs Mariners best bet is on Pena to record 2+ total bases. Make sure to find the best odds by checking our live MLB odds page and be sure to download the Action Network app for more picks and analysis.
Astros vs Mariners Odds
| Astros Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 +155 | 7.5 -115o / -105u | +105 |
| Mariners Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 -190 | 7.5 -115o / -105u | -125 |
- Astros vs Mariners moneyline: Astros +105, Mariners -125
- Astros vs Mariners over/under: 7.5 (-115o / -105u)
- Astros vs Mariners spread: Mariners -1.5 (+155 ), Astros +1.5 (-190)
Astros vs Mariners Probable Pitchers
| Ethan Pecko | Stat | George Kirby |
|---|---|---|
| 1-0 | W-L | 9-11 |
| -0.1 | fWAR (FanGraphs) | 2.5 |
| 3.77 / 4.81 | ERA / xERA | 4.24 / 4.20 |
| 5.51 / 5.34 | FIP / xFIP | 3.85 / 3.93 |
| 6 | K-BB% | 13.8 |
| 38.6 | GB% | 43.8 |
| .192 | BABIP | .335 |
| 99 | Stuff+ | 101 |
| 100 | Location+ | 112 |
Astros vs Mariners MLB Betting Preview
Astros vs Mariners Pick, Betting Analysis
By Prop Model
The total bases prop for Jeremy Pena looks like a strong over wager based on the current data. The line of 1.5 compares favorably with our MLB simulations. The prop projects to hit 51.61% of the time based on the assumptions, and that represents an 11.61% edge.
Pick: Jeremy Pena Over 1.5 Total Bases (+150)
