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Brewers vs Phillies Prediction, Pick, MLB Odds for Tuesday, September 22

Brewers vs Phillies Prediction, Pick, MLB Odds for Tuesday, September 22 article feature image
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Jamie Sabau-Imagn Images. Pictured: Brewers SP Dustin May

The Philadelphia Phillies host the Milwaukee Brewers on September 22, 2026. First pitch from Citizens Bank Park is scheduled for 6:40 p.m. ET. The game will be broadcast on BREW.

The Phillies are favored by -140 on the moneyline and by -1.5 on the run line. The Brewers are +120 on the moneyline and +1.5 on the run line. The total is set at 7 runs.

Find my MLB picks and Brewers vs Phillies prediction below, as well as probable pitchers, weather report, and more.


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Brewers vs Phillies Prediction

  • Brewers vs Phillies Pick: Dustin May Under 10.5 Outs (-110)

My Brewers vs Phillies best bet is Under 10.5 outs for Dustin May in this game. Make sure to find the best odds by checking our live MLB odds page, and download the Action Network app for more picks and analysis.


Brewers vs Phillies Odds

Brewers Logo
Tuesday, Sep 22
6:40 p.m. ET
BREW
Phillies Logo
Brewers Odds
SpreadTotalMoneyline
+1.5
-185
7
-120o / 100u
+120
Phillies Odds
SpreadTotalMoneyline
-1.5
+155
7
-120o / 100u
-140
Odds via bet365. Get up-to-the-minute MLB odds here.
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  • Brewers vs Phillies moneyline: Brewers +120, Phillies -140
  • Brewers vs Phillies over/under: 7 (-120o / +100u)
  • Brewers vs Phillies spread: Brewers +1.5 (-185), Phillies -1.5 (+155)

Brewers vs Phillies Probable Pitchers

Dustin May (RHP, MIL)StatZack Wheeler (RHP, PHI)
7-9W-L13-5
2.9fWAR (FanGraphs)3.5
4.61 / 4.41ERA / xERA2.99 / 2.98
3.50 / 3.94FIP / xFIP3.47 / 3.12
15.0K-BB%21.9
42.4GB%43.4
.321BABIP.264
102Stuff+105
103Location+106

Brewers vs Phillies MLB Betting Preview, Prediction

Brewers starter Dustin May is pitching on short rest after struggling on Friday against the Orioles. Milwaukee has clear piggyback candidates, Shane Drohan and Tanner Gordon.

With a bunch of big lefties at the top of the order, May could be limited to just one trip through the Phillies lineup.

Pick: Dustin May Under 10.5 Outs (-110, bet365)


Brewers vs Phillies Weather


Get the latest coverage on MLB Weather.


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About the Author
Charlie WrightStaff Writer

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