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MLB Best Bets Today: Predictions & Picks for Rays vs Yankees, Guardians vs Red Sox, Padres vs Dodgers, More on Tuesday, September 22

MLB Best Bets Today: Predictions & Picks for Rays vs Yankees, Guardians vs Red Sox, Padres vs Dodgers, More on Tuesday, September 22 article feature image
7 min read
Credit:

Vincent Carchietta, Patrick Gorski, Gregory Fisher, and Kyle Ross-Imagn Images. Pictured: Yankees LF Cody Bellinger (top left), Wrigley Field view (top right), Padres SP Michael King (bottom left), Mets SP Sean Manaea (bottom right)

Our final regular-season Tuesday slate features 16 games, thanks to a Rays vs. Yankees doubleheader that starts at 1:05 p.m ET.

We have a pick for that first game, and also for Guardians vs. Red Sox (6:45 p.m. ET), Marlins vs. Cubs (7:40 p.m. ET), Mets vs. Rangers (8:05 p.m. ET), and Padres vs. Dodgers (10:10 p.m. ET).

Read below for our 5 MLB Best Bets for Tuesday.


MLB Best Bets Today

The team logos in the table below represent each of the matchups that our MLB betting staff is targeting from today's slate of games. Click on the team logos for any of the matchups below to navigate to a specific bet discussed in this article, and download the Action Network app for more picks and analysis.

GameTime (ET)Pick
Tampa Bay Rays LogoNew York Yankees Logo
1:05 PM
Cleveland Guardians LogoBoston Red Sox Logo
6:45 PM
Miami Marlins LogoChicago Cubs Logo
7:40 PM
New York Mets LogoTexas Rangers Logo
8:05 PM
San Diego Padres LogoLos Angeles Dodgers Logo
10:10 PM
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our MLB Odds page, which automatically surfaces the best lines for every game.

Derek Carty's Rays vs Yankees Prop Pick

Tampa Bay Rays Logo
Tuesday, Sept. 22
1:05 PM ET
YES
New York Yankees Logo
Cody Bellinger Over 0.5 Hitter Walks (+330)
bet365 Logo

By Derek Carty

There may be some value on Clay Bellinger's walks prop.

THE BAT X is projecting the Yankees left fielder to record 0.42 walks against the Rays this afternoon, and oddsmakers are implying 0.26.

The model believes there is a 35% chance he records at least 1 walk, so there is value on the over at +330. This play is good down to at least +215.

Love THE BAT X? Get all of Carty's sports betting projections at EV Analytics!

Pick: Cody Bellinger Over 0.5 Hitter Walks (+330)



Charlie Wright's Guardians vs Red Sox Best Bet

Cleveland Guardians Logo
Tuesday, Sept. 22
6:45 PM ET
MLB.TV
Boston Red Sox Logo
Under 6.5 Runs (+102)
FanDuel Logo

By Charlie Wright

The weather is brutal in many places today. In Boston, temperatures are in the 50s with winds blowing in. Those aren't the conditions you want Parker Messick and Payton Tolle facing.

The two young lefties will be followed by two of the league's best bullpens. The Red Sox and Guardians relievers' corps rank in the top 4 in xFIP and SIERA.

Pick: Under 6.5 (+102)



BARTOLO's Marlins vs Cubs Top Projection

Miami Marlins Logo
Tuesday, Sept. 22
7:40 PM ET
MLB.TV
Chicago Cubs Logo
Under 6.5 (-101)
DraftKings  Logo

By Sean Zerillo

BARTOLO shows solid value on the total for this matchup, with a 4.5% edge on the under.

It projects the Marlins for 2.71 runs and the Cubs for 3.37 tonight, bringing the total (6.08) under the 6.5 line.

If you want to dive deeper into this game, check out BARTOLO, Zerillo's new PRO baseball tool that gives you access to all the input data he uses to project games every day.

Pick: Under 6.5 (-101)



Mets vs Rangers Bet Labs Featured System

New York Mets Logo
Tuesday, Sept. 22
8:05 PM ET
MLB.TV
Texas Rangers Logo
Under 8 (-115)
DraftKings  Logo

By Bet Labs

When wind blows in at 5–35 mph, fly balls lose carry and home run rates drop significantly.

Our PRO "Weather: Wind Blowing In" system targets unders in these conditions with totals between 6–11, which matches tonight's conditions for Mets vs. Rangers at Globe Life Field.

It’s a sharp weather-based angle that exploits environmental factors often underweighted in line-setting but that heavily affect scoring outcomes.

Pick: Under 8 (-115)



Doug Ziefel's Padres vs Dodgers Best Bet

San Diego Padres Logo
Tuesday, Sept. 22
10:10 PM ET
MLB.TV
Los Angeles Dodgers Logo
Michael King Under 4.5 Hits Allowed (+120)
BetMGM Logo

By Doug Ziefel

Michael King is having a legitimately excellent season by the exact metric this prop is built on. His full-season profile is elite contact suppression. A 3.45 ERA, a 1.20 WHIP, and, going back to 2025's percentile rankings, that still describe his approach.

A mid-80s percentile ranking in average exit velocity allowed and an 80th-percentile hard-hit rate, all backed by an above-average ground-ball rate. That's a pitcher whose whole competitive edge is limiting hard, clean contact rather than missing bats in bulk, which is exactly the skill that caps hit totals start after start regardless of opponent.

The head-to-head history against these Dodgers is the strongest piece of evidence here. Earlier this season, King stifled this same lineup, going seven innings, allowing four hits, and striking out nine in a 1-0 win over Yamamoto. allowing exactly the number on this line against L.A.'s full-strength order, with room to spare on innings.

His current form supports the same shape. Over his last handful of turns, King has been trending toward exactly this kind of outing: He allowed five hits over seven innings against a Giants team that beat him up early before he retired 18 of 19 batters at one point, four hits allowed in six innings in a win over Atlanta, and surrendered only three hits in seven shutout innings against Houston earlier in the stretch.

San Diego is fighting the Dodgers directly for playoff positioning in their final head-to-head series of the year, which means King is being deployed as the Padres' top option to start this series. They are confident in him, and you can back him confidently as well.

Pick: Michael King Under 4.5 Hits Allowed (+120)



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