HomeRight ArrowMLB

White Sox vs Royals Prediction, Pick, MLB Odds for Tuesday, September 22

White Sox vs Royals Prediction, Pick, MLB Odds for Tuesday, September 22 article feature image
2 min read
Credit:

Sep 16, 2026; Cleveland, Ohio, USA; Chicago White Sox designated hitter Tommy Pham (21) runs the bases after hitting a three run home run off Cleveland Guardians pitcher Parker Messick (77) during there fifth inning at Progressive Field. Mandatory Credit: David Dermer-Imagn Images

The Kansas City Royals host the Chicago White Sox on September 22, 2026. First pitch from Kauffman Stadium is scheduled for 7:40 p.m. EDT. The game will be broadcast on ROYL.

The White Sox are favored by -120 on the moneyline and by -1.5 on the run line. The Royals are -100 on the moneyline and +1.5 on the run line. The total is set at 8 runs.

Find my MLB picks and White Sox vs Royals prediction below, as well as probable pitchers, weather report, and more.


Header First Logo
Header Second Logo

White Sox vs Royals Prediction

  • White Sox vs Royals Pick: Tommy Pham Under 0.5 Hits

My White Sox vs Royals best bet is for Tommy Pham not to record a hit. Make sure to find the best odds by checking our live MLB odds page.


White Sox vs Royals Odds

White Sox Logo
September 22, 2026
7:40 p.m. EDT
ROYL
Royals Logo
White Sox Odds
SpreadTotalMoneyline
-1.5
-170
8
-105o / -115u
-120
Royals Odds
SpreadTotalMoneyline
+1.5
+140
8
-105o / -115u
-100
Odds via DraftKings. Get up-to-the-minute MLB odds here.
DraftKings Logo
  • White Sox vs Royals moneyline: White Sox -120, Royals -100
  • White Sox vs Royals over/under: 8 (-105o / -115u)
  • White Sox vs Royals spread: White Sox -1.5 (+140), Royals +1.5 (-170)

White Sox vs Royals Probable Pitchers

Anthony Kay (LHP, CHW)StatDaniel Lynch IV (LHP, KC)
9-9W-L6-5
1.2fWAR (FanGraphs)1.0
4.41 / 4.98ERA / xERA3.29 / 4.04
4.77 / 4.67FIP / xFIP3.78 / 4.51
10.2%K-BB%9.3%
43.6%GB%47.0%
.286BABIP.232
104Stuff+102
104Location+96

White Sox vs Royals MLB Betting Preview

Header First Logo

White Sox vs Royals Pick, Betting Analysis

By Derek Carty

THE BAT X is forecasting 0.77 hits for White Sox outfielder Tommy Pham compared to 0.92 hits implied by the oddsmakers, so I believe there is value here.

If you take the under, you'd be projected to win 45% of the time, resulting in a 19% ROI. Based on a $100 wager, the expected value here would be $19.32. This play is good down to at least +146.

Pick: Tommy Pham Under 0.5 Hits (+167, DraftKings)


White Sox vs Royals Weather


Get the latest coverage on MLB Weather.
Author Profile
About the Author

Action Network is a team of seasoned sports betting experts specializing in a broad range of sports, from the NFL and NBA to less mainstream options like cricket and darts. Their staff includes well-known analysts like Sean Koerner and Stuckey, recognized for their accurate predictions and deep sports knowledge. The team is dedicated to delivering expert analysis and daily best bets, ensuring bettors are well-informed across all major sports.

This site contains commercial content. We may be compensated for the links provided on this page. The content on this page is for informational purposes only. Action Network makes no representation or warranty as to the accuracy of the information given or the outcome of any game or event.