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Nationals vs Tigers Prediction, Pick, MLB Odds for Tuesday, September 22

Nationals vs Tigers Prediction, Pick, MLB Odds for Tuesday, September 22 article feature image
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John E. Sokolowski-Imagn Images. Pictured: Tigers 2B Hao-Yu Lee

The Detroit Tigers host the Washington Nationals on September 22, 2026. First pitch from Comerica Park is scheduled for 6:40 p.m. ET. The game will be broadcast on NATS.

The Tigers are favored by -155 on the moneyline and by -1.5 on the run line. The Nationals are +130 on the moneyline and +1.5 on the run line. The total is set at 8 runs.

Find my MLB picks and Nationals vs Tigers prediction below, as well as probable pitchers, weather report, and more.


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Nationals vs Tigers Prediction

  • Nationals vs Tigers Pick: Hao-Yu Lee Under 0.5 Hits (+182)

My Nationals vs Tigers best bet is on Hao-Yu Lee to record no hits today. Make sure to find the best odds by checking our live MLB odds page, and download the Action Network app for more picks and analysis.


Nationals vs Tigers Odds

Nationals Logo
Tuesday, Sep 22
6:40 p.m. ET
NATS
Tigers Logo
Nationals Odds
SpreadTotalMoneyline
+1.5
-160
8
-115o / -105u
+130
Tigers Odds
SpreadTotalMoneyline
-1.5
+135
8
-115o / -105u
-155
Odds via bet365. Get up-to-the-minute MLB odds here.
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  • Nationals vs Tigers moneyline: Nationals +130, Tigers -155
  • Nationals vs Tigers over/under: 8 (-115o / -105u)
  • Nationals vs Tigers spread: Nationals +1.5 (-160), Tigers -1.5 (+135)

Nationals vs Tigers Probable Pitchers

Jackson Kent (LHP, WAS)StatDrew Anderson (RHP, DET)
1-4W-L5-6
0.4fWAR (FanGraphs)0.7
6.40 / 5.35ERA / xERA3.62 / 3.79
4.37 / 5.01FIP / xFIP4.19 / 3.84
2.6K-BB%15.2
49.0GB%49.1
.323BABIP.286
87Stuff+97
96Location+100

Nationals vs Tigers MLB Betting Preview, Prediction

By Derek Carty

THE BAT X is forecasting 0.76 hits for Hao-Yu Lee against the Nationals compared to 0.96 hits implied by the oddsmakers, so I believe there is value here for the Tigers 2B.

If you take the under, you'd be projected to win 46% of the time, resulting in a 29% ROI. Based on a $100 wager, the expected value here would be $29.04. This play is good down to at least +140.

Love THE BAT X? Get all of Carty's sports betting projections at EV Analytics!

Pick: Hao-Yu Lee Under 0.5 Hits (+182, bet365)


Nationals vs Tigers Weather


Get the latest coverage on MLB Weather.


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