The Washington Nationals host the Minnesota Twins on May 6, 2026. First pitch from Nationals Park is scheduled for 6:45 p.m. ET. The game will be broadcast on MNNT.
The Twins are favored by -145 on the moneyline and by -1.5 on the run line. The Nationals are +118 on the moneyline and +1.5 on the run line. The total is set at 9.5 runs.
Find my MLB picks and Twins vs Nationals prediction below, as well as probable pitchers, weather report, and more.
Twins vs Nationals Prediction
- Twins vs Nationals Pick: Byron Buxton Over 1.5 Total Bases (-135)
My Twins vs Nationals best bet is on Byron Buxton to record two or more total bases in this game. Make sure to find the best odds by checking our live MLB odds page.
Twins vs Nationals Odds
| Twins Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +120 | 9.5 100o / -120u | -145 |
| Nationals Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -145 | 9.5 100o / -120u | +118 |
- Twins vs Nationals moneyline: Twins -145, Nationals +118
- Twins vs Nationals over/under: 9.5 (+100o / -120u)
- Twins vs Nationals spread: Twins -1.5 (+120), Nationals +1.5 (-145)
Twins vs Nationals Probable Pitchers
| RHP Bailey Ober (MIN) | Stat | RHP Miles Mikolas (WAS) |
|---|---|---|
| 3-1 | W-L | 0-3 |
| 0.7 | fWAR (FanGraphs) | -0.6 |
| 3.55 / 3.81 | ERA / xERA | 8.23 / 5.20 |
| 4.17 / 4.64 | FIP / xFIP | 6.77 / 4.73 |
| 10.2 | K-BB% | 6.3 |
| 38.1 | GB% | 47.9 |
| .239 | BABIP | .315 |
| 94 | Stuff+ | 90 |
| 88 | Location+ | 115 |
Twins vs Nationals MLB Betting Preview
Despite a rather sluggish start to this 2026 campaign, Byron Buxton is beginning to find his rhythm at the plate. He’s smashed five homers over the past eight games.
In addition to his current form, the Twins center fielder gets an ideal matchup on Wednesday against Nationals SP Miles Mikolas.
Mikolas has a whopping 8.23 ERA and 1.72 WHIP over his first seven starts. Not a great omen, considering he has posted an ERA over four in six of his past seven full seasons.
While Buxton does not have the best head-to-head history versus Mikolas, having failed to record a single hit in his five career head-to-head plate appearances, he should take advantage of this version of Mikolas.
Twins vs Nationals Pick, Betting Analysis
Mikolas is on pace for a career-low strikeout rate and a career-high hard-hit rate allowed, ultimately equating to an obscene 2.63 HR/9 allowed.
Buxton is one of the best barrel guys in the game, so I wouldn’t be surprised to see him blast an extra-base (or home run) on Wednesday.
Pick: Byron Buxton Over 1.5 Total Bases (-135, BetMGM)
