The Chicago White Sox host the Washington Nationals on April 25, 2026. First pitch from Rate Field is scheduled for 4:10 p.m. EDT. The game will be broadcast on CHSN.
The White Sox are favored by -142 on the moneyline and by -1.5 on the run line. The Nationals are +120 on the moneyline and +1.5 on the run line. The total is set at 8.5 runs.
Find my MLB picks and Nationals vs White Sox prediction below, as well as probable pitchers, weather report, and more.
Nationals vs White Sox Prediction
- Nationals vs White Sox Pick: Miguel Vargas 1+ Home Runs
My Nationals vs White Sox best bet is on Miguel Vargas to hit at least one home run. Make sure to find the best odds by checking our live MLB odds page.
Nationals vs White Sox Odds
| Nationals Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 +145 | 8.5 -100o / -117u | +120 |
| White Sox Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 -175 | 8.5 -100o / -117u | -142 |
- Nationals vs White Sox moneyline: Nationals +120, White Sox -142
- Nationals vs White Sox over/under: 8.5 (-100o / -117u)
- Nationals vs White Sox spread: White Sox -1.5 (+145 ), Nationals +1.5 (-175)
Nationals vs White Sox Probable Pitchers
| RHP Jake Irvin (WSN) | Stat | LHP Noah Schultz (CHW) |
|---|---|---|
| 1-3 | W-L | 1-1 |
| 0.1 | fWAR (FanGraphs) | 0.2 |
| 6.00/5.59 | ERA / xERA | 3.86/2.58 |
| 4.96/4.52 | FIP / xFIP | 3.99/3.97 |
| 13.2% | K-BB% | 13.2% |
| 35.8% | GB% | 31.8% |
| .254 | BABIP | .136 |
| 101 | Stuff+ | 102 |
| 95 | Location+ | 96 |
Nationals vs White Sox MLB Betting Preview
Washington turns to right-hander Jake Irvin (1-3, 6.00 ERA) on the mound. Irvin has struggled with consistency through five starts, particularly with the long ball; he has surrendered four home runs in just 24 innings this season, following a 2025 campaign where he led the league with 38 home runs allowed.
Chicago will counter with top prospect Noah Schultz (1-1, 3.86 ERA), who has provided a stabilizing presence in the rotation with a 0.96 WHIP and superior command.
While both offenses have had their share of "opposite day" struggles this season, the pitching edge sits firmly with the home side as Irvin looks to navigate a dangerous Chicago lineup that is starting to find its rhythm.
Nationals vs White Sox Pick, Betting Analysis
Miguel Vargas comes into this game in great form, and the spot here is a good one.
While I prefer to target lefties vs. Irvin, he's still a plus matchup for Vargas. Irvin's inability to keep the ball in the yard makes any power-hitting righty a threat.
Despite the chilly 48°F temperatures expected at Rate Field, the conditions are more hitter-friendly than they appear. The wind is gusting at 16 mph from the North, which often translates to a significant "blowing out" effect toward the outfield gaps.
We have the true odds on Vargas around +500.
Pick: Miguel Vargas 1+ Home Runs
