The Chicago Cubs (22-15) host the San Francisco Giants (23-14) on Wednesday, May 7, 2025. First pitch from Wrigley Field is scheduled for 2:20 p.m. ET; the game will be broadcast on NBCS-BA.
Find my Cubs vs Giants prediction for Wednesday below.
Cubs vs Giants Predictions, Picks for Wednesday
- Giants vs Cubs pick:Cubs Moneyline (-130 | Play to -135)
My Giants vs Cubs best bet is Cubs ML. Make sure to find the best odds by checking our live MLB odds page.
Cubs vs Giants Odds, Lines
| Cubs Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +150 | 7 -115o / -105u | -160 |
| Giants Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -185 | 7 -115o / -105u | +135 |
Cubs vs Giants Projected Starting Pitchers
| LHP Robbie Ray (SF) | Stat | RHP Ben Brown (CHC) |
|---|---|---|
| 4-0 | W-L | 3-2 |
| 0.3 | fWAR (FanGraphs) | 0.5 |
| 3.05 / 3.74 | ERA /xERA | 4.88 / 4.40 |
| 4.26 / 4.16 | FIP / xFIP | 3.70 / 3.82 |
| 1.25 | WHIP | 1.66 |
| 12.7% | K-BB% | 14.3% |
| 43.8% | GB% | 46.3% |
| 98 | Stuff+ | 95 |
| 87 | Location+ | 94 |
Cubs vs Giants Preview, Wednesday Prediction
Giants Betting Insights
Left-hander Robbie Ray takes the mound for the San Francisco Giants, and he should serve as a strong sell-high candidate. Ray is 4-0 with a 3.05 ERA through seven starts this season.
However, he has benefited from strong defensive play behind him. Entering this matchup, Ray owns a 4.26 fielding independent pitching (FIP) and a 4.16 expected FIP (xFIP).
Furthermore, his underlying metrics suggest that regression is likely. Ray ranks in the bottom fifth of the league in average exit velocity, walk rate, barrel rate and hard-hit rate.
San Francisco may also struggle to provide Ray with solid run support. This season, the Giants rank in the bottom half of the league in hits per game, batting average, on-base percentage, slugging percentage and OPS.
Cubs Betting Insights
Speaking of lineups, the Chicago Cubs clearly hold the hitting advantage in this matchup. They rank in the top three in runs scored per game, hits per game, batting average, on-base percentage, slugging percentage, OPS, home runs and stolen bases.
It is arguably the best lineup in baseball, and it should capitalize on Ray’s expected regression.
While Ray is due for regression, Chicago’s starting pitcher, Ben Brown, is due for positive regression. Despite some early struggles, Brown outperforms Ray in average exit velocity, walk rate, barrel rate and hard-hit rate.
Even if you give the edge to Ray, the gap between the two lineups is far greater than the gap between the starting pitchers.
Finally, through 102 combined plate appearances against Ray, this current Cubs roster boasts a .494 slugging percentage and a .464 expected slugging percentage (xSLG).
Cubs vs Giants Prediction, Moneyline Pick
Chicago’s offense can put up runs against anyone, and it should have no issue doing so again in this matchup. Not only does this Cubs lineup have a strong track record against Ray, but the left-hander is also due for regression.
On the other hand, Brown’s analytics are stronger than his surface-level stats suggest. Ray may still hold a slight edge on the mound, but it is not nearly as large as the offensive advantage in favor of Chicago.
Pick: Cubs ML (-130 | Play to -135)
Moneyline
As mentioned, I'm betting on the Cubs moneyline.
Run Line (Spread)
I also like Chicago to cover, but find more value in just taking the outright ML price.
Over/Under
I lean toward the Over, but I don't trust San Francisco's lineup.
Cubs vs Giants Betting Trends
Cubs vs Giants Viewing Info: Channel, Start Time, Streaming
| Location: | Wrigley Field in Chicago, Ill. |
| Date: | Wednesday, May 7 |
| Time: | 2:20 p.m. ET |
| TV / Streaming Options: | NBCS BA, Marquee; MLB.TV |
