HomeRight ArrowMLB

Cardinals vs Yankees Prediction, Pick, MLB Odds for Wednesday, August 5

Cardinals vs Yankees Prediction, Pick, MLB Odds for Wednesday, August 5 article feature image
2 min read
Credit:

Aug 4, 2026; Bronx, New York, USA; New York Yankees second baseman Jazz Chisholm Jr. (13) runs the bases after hitting a solo home run during the second inning against the St. Louis Cardinals at Yankee Stadium. Mandatory Credit: Vincent Carchietta-Imagn Images

The New York Yankees host the St. Louis Cardinals on August 5, 2026. First pitch from Yankee Stadium is scheduled for 7:05 p.m. EDT. The game will be broadcast on CARD.

The Yankees are -154 on the moneyline and -1.5 on the run line. The Cardinals are +142 on the moneyline and +1.5 on the run line. The total is set at 8.5 runs.

Find my MLB picks and Cardinals vs Yankees prediction below, as well as probable pitchers, weather report, and more.


Header First Logo
Header Second Logo

Cardinals vs Yankees Prediction

Cardinals vs Yankees Picks:

  • Yankees ML
  • Jazz Chisholm Over 1.5 HRR

Cardinals vs Yankees Odds

Cardinals Logo
Wednesday, Aug 5
7:05 p.m. ET
CARD
Yankees Logo
Cardinals Odds
SpreadTotalMoneyline
+1.5
-156
8.5
-108o / -112u
+142
Yankees Odds
SpreadTotalMoneyline
-1.5
+130
8.5
-108o / -112u
-154
Odds via FanDuel. Get up-to-the-minute MLB odds here.
FanDuel Logo


Cardinals vs Yankees Probable Pitchers

Andre Pallante (RHP, STL)StatWill Warren (RHP, NYY)
11-6W-L8-5
2.0fWAR (FanGraphs)1.5
3.72 / 3.73ERA / xERA4.14 / 4.45
3.75 / 4.00FIP / xFIP3.96 / 3.77
10.5%K-BB%15.4%
55.4%GB%43.1%
.281BABIP.313
98Stuff+104
106Location+106

Cardinals vs Yankees MLB Betting Preview

The Yankees will host the Cardinals on Wednesday night to conclude a three-game interleague set at Yankee Stadium in the Bronx. Will Warren will start for New York, while Andre Pallante will start for St. Louis.

Pallante has been better than Warren this season (3.72 ERA, 1.22 WHIP, 119 IP), but Warren is a volatile pitcher who has had a few blow-up starts that have inflated his 4.14 ERA.

Under the hood, I project Warren as the better starting pitcher between the two.

Additionally, this Yankee lineup has fared well against Pallante (.391 wOBA across 50 head-to-head plate appearances).

One Yankee I expect to have a big game is Jazz Chisholm Jr.

Though he’s gotten off to a sluggish start this season, he’s started to see the ball better of late, and he’s already hit a homer off Pallante in the past.

Picks:

  • Yankees ML
  • Jazz Chisholm Over 1.5 HRR

Cardinals vs Yankees Weather


Get the latest coverage on MLB Weather.
Author Profile
About the Author

Ryan graduated from Providence College in 2016 with Bachelor Degrees in Business Economics & Mathematics. It was at Providence where Ryan really first found his passion for sports betting. For a lifelong sports fan with a knack for statistical analysis, he was instantly drawn to the fundamentals of the industry, specifically how sports betting markets functioned and fluctuated. In what primarily started as a recreational hobby, Ryan began studying the ins-and-outs of sports betting markets on a daily basis. He took to Twitter (now X), where he amassed a following for writing a sports betting blog that provided statistical analysis behind his wagers. In spite of seeking employment opportunities elsewhere post graduation, Ryan continued to follow his passion for the statistical analysis of sports betting wagers, eventually deciding to pursue a career in the sports betting industry.

This site contains commercial content. We may be compensated for the links provided on this page. The content on this page is for informational purposes only. Action Network makes no representation or warranty as to the accuracy of the information given or the outcome of any game or event.