The Chicago Cubs host the Toronto Blue Jays on June 21, 2026. First pitch from Wrigley Field is scheduled for 2:20 p.m. EDT. The game will be broadcast on SNET.
The Blue Jays are favored by -122 on the moneyline and by -1.5 on the run line. The Cubs are +101 on the moneyline and +1.5 on the run line. The total is set at 6.5 runs.
Find my MLB picks and Blue Jays vs Cubs prediction below, as well as probable pitchers, weather report, and more.
Blue Jays vs Cubs Prediction
- Blue Jays vs Cubs Pick: Vladimir Guerrero Jr. Over 1.5 Total Bases
My Blue Jays vs Cubs best bet is on Vladdy's prop. Make sure to find the best odds by checking our live MLB odds page.
Blue Jays vs Cubs Odds
| Blue Jays Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +143 | 6.5 -118o / -102u | -122 |
| Cubs Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -174 | 6.5 -118o / -102u | +101 |
- Blue Jays vs Cubs moneyline: Blue Jays -122, Cubs +101
- Blue Jays vs Cubs over/under: 6.5 (-118 / -102)
- Blue Jays vs Cubs spread: Blue Jays -1.5 (+143), Cubs +1.5 (-174)
Blue Jays vs Cubs Probable Pitchers
| RHP Dylan Cease (TOR) | Stat | LHP Shota Imanaga (CHC) |
|---|---|---|
| 4-3 | W-L | 4-6 |
| 2.6 | fWAR (FanGraphs) | 0.9 |
| 2.71 / 3.02 | ERA / xERA | 4.26 / 3.64 |
| 2.37 / 2.53 | FIP / xFIP | 4.58 / 3.87 |
| 26.1% | K-BB% | 17.8% |
| 45.6% | GB% | 38.2% |
| .331 | BABIP | .238 |
| 108 | Stuff+ | 93 |
| 98 | Location+ | 108 |
Blue Jays vs Cubs MLB Betting Preview
The Blue Jays and Cubs will square off on Sunday afternoon to finish the last of a three-game set at Wrigley Field in Chicago. We get a fun starting pitching matchup in this one, with Dylan Cease facing off against Shota Imanaga.
After a down 2025 in San Diego, Cease has bounced back this season, recording a 2.71 ERA behind 110 strikeouts, the third-most among MLB pitchers.
Unfortunately, the same can’t be said of Imanga, who has continually gotten worse with each season in the big leagues.
- 2024: 2.91 ERA, 3.72 FIP
- 2025: 3.73 ERA, 4.86 FIP
- 2026: 4.26 ERA, 4.58 FIP
Thus, I’m looking to fade Imanaga in this matchup.
Blue Jays vs Cubs Pick, Betting Analysis
Vladimir Guerrero Jr. matches up well with Imanaga’s arsenal.
Imanaga relies on pitches with late-breaking movement off the plate to force chases (37%, 97th percentile), but that won’t work against Vladdy, who is one of the most patient hitters in the game (10% strikeout rate, 11% walk rate).
Thus, I expect Imanaga will have to attack Guerrero over the plate eventually, and Vladdy punishes pitches left over the heart of the plate.
Pick: Vladimir Guerrero Jr. Over 1.5 Total Bases (+113)
