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Blue Jays vs Angels Prediction, Pick, MLB Odds for Wednesday, April 22

Blue Jays vs Angels Prediction, Pick, MLB Odds for Wednesday, April 22 article feature image
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Apr 19, 2026; Phoenix, Arizona, USA; Detailed view of the jersey of Toronto Blue Jays first baseman Vladimir Guerrero Jr (27) against the Arizona Diamondbacks at Chase Field. Mandatory Credit: Mark J. Rebilas-Imagn Images

The Los Angeles Angels host the Toronto Blue Jays on April 22, 2026. First pitch from Angel Stadium is scheduled for 3:07 p.m. EDT. The game will be broadcast on SNET.

The Angels are favored by -152 on the moneyline and by -1.5 on the run line. The Blue Jays are +128 on the moneyline and +1.5 on the run line. The total is set at 8.5 runs.

Find my MLB picks and Blue Jays vs Angels prediction below, as well as probable pitchers, weather report, and more.


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Blue Jays vs Angels Prediction

  • Blue Jays vs Angels Pick: Blue Jays ML (+120 or Better)

My Blue Jays vs Angels best bet is on the Blue Jays. Make sure to find the best odds by checking our live MLB odds page.


Blue Jays vs Angels Odds

Blue Jays Logo
Wednesday, Apr 22
3:07 p.m. ET
SNET
Angels Logo
Blue Jays Odds
SpreadTotalMoneyline
+1.5
-166
8.5
-100o / -122u
+128
Angels Odds
SpreadTotalMoneyline
-1.5
+138
8.5
-100o / -122u
-152
Odds via FanDuel. Get up-to-the-minute MLB odds here.
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  • Blue Jays vs Angels moneyline: Blue Jays +128, Angels -152
  • Blue Jays vs Angels over/under: 8.5 (-100 / -122)
  • Blue Jays vs Angels spread: Angels -1.5 (+138), Blue Jays +1.5 (-166)

Blue Jays vs Angels Pitchers

Eric Lauer (LHP, TOR)StatJosé Soriano (RHP, LAA)
1-3W-L5-0
-0.1fWAR (FanGraphs)1.1
7.13 / 4.48ERA / xERA0.28 / 2.72
5.96 / 5.04FIP / xFIP2.34 / 2.82
7.6%K-BB%21.7%
27.5%GB%58.2%
.245BABIP.149
86Stuff+104
98Location+107

Blue Jays vs Angels MLB Betting Preview

Sorry. I’m not buying it with Jose Soriano.

He is a quality starting pitcher. He is not a Cy Young candidate. He still walks too many batters (11% rate), and if it weren’t for his .149 BABIP and 100% strand rate, his ERA would be sitting closer to three or four — projections place him with around a 3.60 ERA for the remainder of the season.

I think he’s due for a blowup start, while I believe the Blue Jays are starting to find their stride on offense. This lineup is too talented to struggle this mightily for the remainder of the season.


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Blue Jays vs Angels Pick, Betting Analysis

My numbers give the Blue Jays advantages in the bullpen, on defense, and on the base paths.

As a result, I actually project Toronto as a favorite in this game.

Our own Sean Zerillo projects the Blue Jays closer to +115, so I’m willing to take a shot with the Jays at +120 or better.

Pick: Blue Jays ML (+120 or Better)

Playbook

Blue Jays vs Angels Weather


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Author Profile
About the Author

Tanner McGrath covers college basketball, college football and Major League Baseball at Action Network. He is a contributor to Payoff Pitch, Action Network’s Major League Baseball betting podcast. He's been working in the space for more than five years with past journalism experience in Canadian collegiate sports, finance and economics. He has an obsession with America East basketball, betting the Miami Marlins and sweating out home underdogs.

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