The Baltimore Orioles host the Washington Nationals on May 16, 2025. First pitch from Oriole Park at Camden Yards is scheduled for 7:05 p.m. EDT; the game will be broadcast on MASN.
Read our Nationals vs Orioles prediction and MLB player prop picks below.
My Nationals vs Orioles Prediction
- Nationals vs Orioles Picks: Gunnar Henderson Over 0.5 Home Runs (+500, bet365)
My Nationals vs Orioles best bet is on Gunnar Henderson to hit a home run. Check our live MLB odds page to find the best odds.
Nationals vs Orioles Odds
| Nationals Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +165 | 9 -105o / -115u | +105 |
| Orioles Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -200 | 9 -105o / -115u | -125 |
Grant Neiffer’s Nationals vs Orioles Preview
Baltimore Orioles Player Prop: Homer Henderson
Typically, I’d avoid this bet because of the lefty-on-lefty matchup.
But the odds for Gunnar Henderson to hit a homer are too good to pass up.
MacKenzie Gore is a good pitcher, but he’s been an above-average matchup for power and has decent reverse splits. He’s allowed 1.26 home runs per nine innings pitched to left-handed hitters in his career, and Camden Yards is a good park for lefty power.
The weather is a concern, but RotoGrinders Chief Meteorologist Kevin Roth projects that it should be solid-enough hitting weather.
I make the fair odds on this home run prop shorter than +450.
Pick: Gunnar Henderson Over 0.5 Home Runs (+500, bet365)
