The Baltimore Orioles host the Toronto Blue Jays on September 21, 2026. First pitch from Oriole Park at Camden Yards is scheduled for 6:35 p.m. EDT. The game will be broadcast on MASN.
The Blue Jays are favored by -113 on the moneyline and by -1.5 on the run line. The Orioles are -105 on the moneyline and +1.5 on the run line. The total is set at 7.5 runs.
Find my MLB picks and Blue Jays vs Orioles prediction below, as well as probable pitchers, weather report, and more.
Blue Jays vs Orioles Prediction
- Blue Jays vs Orioles Pick: Blue Jays Moneyline
My Blue Jays vs Orioles best bet is on Toronto to win outright. Make sure to find the best odds by checking our live MLB odds page and download our Action Network app to find out the latest picks and expert analysis.
Blue Jays vs Orioles Odds
| Blue Jays Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 -190 | 7.5 -115o / -105u | -105 |
| Orioles Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 +156 | 7.5 -115o / -105u | -113 |
- Blue Jays vs Orioles moneyline: Blue Jays -105, Orioles -113
- Blue Jays vs Orioles over/under: 7.5 (-115o / -105u)
- Blue Jays vs Orioles spread: Blue Jays -1.5 (+156), Orioles +1.5 (-190)
Blue Jays vs Orioles Probable Pitchers
| Trey Yesavage (RHP, TOR) | Stat | Shane Baz (RHP, BAL) |
|---|---|---|
| 5-5 | W-L | 6-15 |
| 1.3 | fWAR (FanGraphs) | 3.3 |
| 3.65 / 3.38 | ERA / xERA | 4.11 / 4.20 |
| 4.08 / 4.63 | FIP / xFIP | 3.61 / 4.27 |
| 11.7% | K-BB% | 12.4% |
| 33.9% | GB% | 37.4% |
| .215 | BABIP | .312 |
| 108 | Stuff+ | 98 |
| 90 | Location+ | 103 |
Blue Jays vs Orioles MLB Betting Preview
The Toronto Blue Jays hand the ball to right-hander Trey Yesavage, who has been fantastic in his first full campaign. Through 18 starts, the former first-round draft pick boasts a 3.65 ERA and a 1.14 WHIP.
His underlying metrics are equally impressive. Entering this matchup, Yesavage owns a 3.38 xERA and a .200 xBA.
The right-hander also ranks in the top quarter of the league in whiff rate, barrel rate and hard-hit rate.
Meanwhile, right-hander Shane Baz gets the ball for the Baltimore Orioles. His 2026 season has gone far differently, as Baz is 6-15 with a 4.11 ERA and a 1.35 WHIP through 30 starts.
He also trails Yesavage in xERA, xBA, barrel rate and hard-hit rate.
While Baltimore is the stronger hitting team, the gap is not nearly as wide as the one on the mound. This season, both teams rank in the bottom half of the league in on-base percentage, slugging percentage and OPS.
Pick: Blue Jays Moneyline
