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MLB Best Bets Today: Predictions & Picks for Blue Jays vs Orioles, Nationals vs Tigers, Twins vs Giants on Monday, September 21

MLB Best Bets Today: Predictions & Picks for Blue Jays vs Orioles, Nationals vs Tigers, Twins vs Giants on Monday, September 21 article feature image
4 min read
Credit:

David Frerker, Daniel Kucin Jr., Matt Marton, and Stan Szeto-Imagn Images. Pictured: Blue Jays SP Trey Yesavage (top left), Autographed baseballs at Camden Yards, (top right), Tigers 2B Hao-Yu Lee (bottom left), Giants SP Blade Tidwell (bottom right)

MLB's regular season is winding down, and the battle for playoff berths is heating up.

On Monday, with only three games on the slate, we have picks for each of them: Blue Jays vs. Orioles (6:35 p.m. ET, Camden Yards), Nationals vs. Tigers (6:40 p.m. ET, Comerica Park), and Twins vs. Giants (9:45 p.m. ET, Oracle Park).

Read below for our 3 MLB Best Bets.


MLB Best Bets Today

The team logos in the table below represent each of the matchups that our MLB betting staff is targeting from today's slate of games. Click on the team logos for any of the matchups below to navigate to a specific bet discussed in this article, and download the Action Network app for more picks and analysis.

GameTime (ET)Pick
Toronto Blue Jays LogoBaltimore Orioles Logo
6:35 PM
Washington Nationals LogoDetroit Tigers Logo
6:40 PM
Minnesota Twins LogoSan Francisco Giants Logo
9:45 PM
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our MLB Odds page, which automatically surfaces the best lines for every game.

Tony Sartori's Blue Jays vs Orioles Best Bet

Toronto Blue Jays Logo
Monday, Sept. 21
6:35 PM ET
MLB.TV
Baltimore Orioles Logo
Blue Jays ML (+100)
FanDuel Logo

By Tony Sartori

The Toronto Blue Jays hand the ball to right-hander Trey Yesavage, who has been fantastic in his first full campaign. Through 18 starts, the former first-round draft pick boasts a 3.65 ERA and a 1.14 WHIP.

His underlying metrics are equally impressive. Entering this matchup, Yesavage owns a 3.38 xERA and a .200 xBA.

The right-hander also ranks in the top quarter of the league in whiff rate, barrel rate, and hard-hit rate.

Meanwhile, right-hander Shane Baz gets the ball for the Baltimore Orioles. His 2026 season has gone far differently, as Baz is 6-15 with a 4.11 ERA and a 1.35 WHIP through 30 starts.

He also trails Yesavage in xERA, xBA, barrel rate, and hard-hit rate.

While Baltimore is the stronger hitting team, the gap is not nearly as wide as the one on the mound. This season, both teams rank in the bottom half of the league in on-base percentage, slugging percentage, and OPS.

Pick: Blue Jays ML (+100 | Play to -105)



Derek Carty's Prop Pick

Washington Nationals Logo
Monday, Sept. 21
6:40 PM ET
MLB.TV
Detroit Tigers Logo
Hao-Yu Lee Under 0.5 Hits (+160)
bet365 Logo

By Derek Carty

There is a value opportunity on Hao-Yu Lee's hits prop.

THE BAT X is projecting the Tigers 2B to record 0.67 hits, while oddsmakers are implying 0.91.

The model believes there's a 51% chance Lee does not record a hit against the Nationals, so the under has value at +160. This play is good down to at least +116.

Love THE BAT X? Get all of Carty's sports betting projections at EV Analytics!

Pick: Hao-Yu Lee Under 0.5 Hits (+160)



BARTOLO's Twins vs Giants O/U Projection

Minnesota Twins Logo
Monday, Sept. 21
9:45 PM ET
MLB.TV
San Francisco Giants Logo
Under 8 (-102)
DraftKings Logo

By Sean Zerillo

BARTOLO's projections show solid value on the total for today's third and final MLB game, projecting the Twins for 4.14 runs and the Giants for 3.55, which would bring the total to 7.69, well under the current 8 line.

If you want to dive deeper into this game, it'd be wise to check out BARTOLO, Zerillo's new PRO baseball tool that gives you access to all the input data he uses to project games every day.

Pick: Under 8 (-102)



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