The San Francisco Giants host the Minnesota Twins on September 21, 2026. First pitch from Oracle Park is scheduled for 9:45 p.m. EDT. The game will be broadcast on NBCS-BA.
The Twins are favored by -119 on the moneyline and by -1.5 on the run line. The Giants are -102 on the moneyline and +1.5 on the run line. The total is set at 8 runs.
Find my MLB picks and Twins vs Giants prediction below, as well as probable pitchers, weather report, and more.
Twins vs Giants Prediction
- Twins vs Giants Pick: Over 8
My Twins vs Giants best bet is on game totals. Find the best odds on our live MLB odds page, and download our Action Network app for the latest picks and betting analysis from our experts.
Twins vs Giants Odds
| Twins Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 -170 | 8 -117o / -105u | -119 |
| Giants Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 +140 | 8 -117o / -105u | -102 |
- Twins vs Giants moneyline: Twins -119, Giants -102
- Twins vs Giants over/under: 8 (-117o / -105u)
- Twins vs Giants spread: Twins -1.5 (+140), Giants +1.5 (-170)
Twins vs Giants Probable Pitchers
| Zebby Matthews (RHP, MIN) | Stat | Blade Tidwell (RHP, SFG) |
|---|---|---|
| 9-10 | W-L | 1-2 |
| 0.6 | fWAR (FanGraphs) | 0.4 |
| 4.74 / 4.47 | ERA / xERA | 4.56 / 4.50 |
| 4.80 / 4.14 | FIP / xFIP | 4.75 / 4.94 |
| 13.0% | K-BB% | 9.5% |
| 42.4% | GB% | 37.3% |
| .269 | BABIP | .247 |
| 95 | Stuff+ | 102 |
| 101 | Location+ | 91 |
Twins vs Giants MLB Betting Preview
Right-hander Zebby Matthews takes the mound for the Minnesota Twins and should serve as a good fade candidate. He's struggled mightily across his first three seasons in MLB, posting a 15-20 record with a 5.31 ERA and a 1.39 WHIP.
Matthews' underlying metrics suggest that brighter days are unlikely. Entering this matchup, the right-hander ranks in the 31st percentile in xERA, the 37th percentile in xBA, and the 6th percentile in average exit velocity and barrel rate.
The good news for Matthews is that he should receive plenty of run support. This season, Minnesota ranks in the top half of the league in runs scored per game, hits per game, slugging percentage and OPS.
The Twins' success at the plate is likely to continue against right-hander Blade Tidwell, who gets the ball for the San Francisco Giants. Through 20 appearances across his first two seasons, Tidwell is 2-3 with a 5.53 ERA and a 1.42 WHIP.
This year, Tidwell ranks in the 30th percentile in xERA, 45th percentile in xBA, seventh percentile in barrel rate and 47th percentile in hard-hit rate.
Pick: Over 8
