The Detroit Tigers host the Washington Nationals on September 21, 2026. First pitch from Comerica Park is scheduled for 6:40 p.m. ET. The game will be broadcast on NATS.
The Tigers are favored by -152 on the moneyline and by -1.5 on the run line. The Nationals are +128 on the moneyline and +1.5 on the run line. The total is set at 8.5 runs.
Find my MLB picks and Nationals vs Tigers prediction below, as well as probable pitchers, weather report, and more.
Nationals vs Tigers Prediction
- Nationals vs Tigers Pick: Nationals Under 3.5 Runs (-104 | Play to -115)
My Nationals vs Tigers best bet is on Washington to score three or fewer runs today. Make sure to find the best odds by checking our live MLB odds page, and download the Action Network app for more picks and analysis.
Nationals vs Tigers Odds
| Nationals Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -172 | 8.5 -100o / -122u | +128 |
| Tigers Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +142 | 8.5 -100o / -122u | -152 |
- Nationals vs Tigers moneyline: Nationals +128, Tigers -152
- Nationals vs Tigers over/under: 8.5 (-100o / -122u)
- Nationals vs Tigers spread: Nationals +1.5 (-172), Tigers -1.5 (+142)
Nationals vs Tigers Probable Pitchers
| DJ Herz (LHP, WAS) | Stat | River Ryan (RHP, DET) |
|---|---|---|
| (Season debut) | W-L | (Season debut) |
| fWAR (FanGraphs) | ||
| ERA / xERA | ||
| FIP / xFIP | ||
| K-BB% | ||
| GB% | ||
| BABIP | ||
| Stuff+ | ||
| Location+ |
Nationals vs Tigers MLB Betting Preview, Prediction
While the Washington Nationals possess a tremendous offense, they are running into right-hander River Ryan. The No. 5-ranked prospect in the Detroit Tigers' organization, Ryan was a force in his debut campaign before injuries sidelined him.
Through his first four starts in 2024, Ryan was 1-0 with a 1.33 ERA and a 1.18 WHIP. His underlying metrics were equally impressive.
If he had qualified, Ryan would have finished the year in the top half of the league in xERA, xBA, average exit velocity, and hard-hit rate.
He threw nearly 10 innings in spring training this year, allowing just two earned runs while striking out 12 over that stretch.
Pick: Nationals Under 3.5 Runs (-104, FanDuel | Play to -115)
