LA Galaxy vs. Columbus Odds & Betting Predictions - April 22, 2026

LA Galaxy at Columbus

11:30 pm

LA Galaxy

2-3-3

@

Columbus Crew

1-4-3

MatchupOpenSpreadTotalMoneyline
LA Galaxy 2-3-3	+1.5	+0.5-102	o3.5+130	+300
Columbus 1-4-3	u3.5	-0.5-135	u3.5-167	-130

location pin

Wednesday 11:30 p.m.

April 22, 2026

ScottsMiracle-Gro FieldColumbus, OH

MLS Public Betting

Columbus are 1-2 in their last 5 games.
Columbus are 1-4 in their last 5 games against the spread
Columbus are 1-4 in their road games against the spread
The totals have gone OVER in 4 of Columbus' last 5 games
The totals have gone OVER in 0 of Columbus' 3 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Columbus	1-7	0-3	1-4	1-7	N/A
LA Galaxy	3-5	1-3	2-2	1-3	2-2

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Columbus	5-3	0-3	5-0	5-3	N/A
LA Galaxy	5-3	2-2	3-1	2-2	3-1

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Columbus	1-4	0-1-2	1-3-1	1-4-3	N/A
LA Galaxy	2-3	1-2-1	1-1-2	1-2-1	1-1-2

date	opponent	score	spread	over/under	moneyline
Apr 18th	@NE	L 1-2	-0.5 L	O 2.5	NE +123
Apr 12th	ORL	W 1-1	-1.5 L	U 3.5	ORL -232
Apr 4th	@ATL	W 3-1	-0.5 W	O 2.5	CLB +125
Mar 21st	@TOR	L 1-2	-0.5 L	O 2.5	TOR +125
Mar 14th	NSH	L 0-1	-0.5 L	U 2.5	NSH -165

Douglas Costa
MID
Metatarsal Fracture
Out Indefinitely
R. Alessandrini
MID
MCL Knee Ligament Injury
Out Indefinitely
N. DePuy
DEF
DePuy is injured
Out Indefinitely

See more MLS Injuries

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MatchupOverUnder
LA Galaxy 2-3-3	N/A	N/A
Columbus 1-4-3	N/A	N/A