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LA Galaxy vs. Columbus Odds & Betting Predictions - April 22, 2026

LA Galaxy at Columbus

11:30 pm

LA Galaxy

11-11-11
1
1 - 2

Columbus Crew

13-15-5
2

LA Galaxy at Columbus Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
LA Galaxy
11-11-11
+1.5
+1.5-250
o3.5+130
+360
Columbus
13-15-5
u3.5
-1.5+182
u3.5-161
-155
location pinWednesday 11:30 p.m.
April 22, 2026
ScottsMiracle-Gro FieldColumbus

Prop Odds Comparison

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Line Movement Tracker

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LA Galaxy vs. Columbus Public Betting Percentages

Away Logo

LA Galaxy

Public

Home Logo

Columbus

15%

Bets%

85%

Money%

MLS Public Betting Right Arrow

Betting Trends

  • Columbus are 2-1 in their last 5 games.
  • Columbus are 2-3 in their last 5 games against the spread
  • Columbus are 5-10 in their road games against the spread
  • The totals have gone OVER in 2 of Columbus' last 5 games
  • The totals have gone OVER in 7 of Columbus' 17 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Columbus		13-19-18-95-10-19-144-5-1
LA Galaxy		16-176-1110-65-1011-7

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Columbus		19-147-1012-413-106-4
LA Galaxy		17-14-27-9-110-5-18-79-7-2

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Columbus		13-159-6-24-9-310-10-33-5-2
LA Galaxy		11-117-4-64-7-56-4-55-7-6

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Apr 18th@NEL 1-2-0.5 LO 2.5NE +123
Apr 12thORLW 1-1-1.5 LU 3.5ORL -232
Apr 4th@ATLW 3-1-0.5 WO 2.5CLB +125
Mar 21st@TORL 1-2-0.5 LO 2.5TOR +125
Mar 14thNSHL 0-1-0.5 LU 2.5NSH -165

Columbus vs. LA Galaxy Injury Updates

Columbus Injuries

  • E. Boateng
    MID

    Boateng is out with knock injury

    Out

LA Galaxy Injuries

  • Douglas Costa
    MID

    Metatarsal Fracture

    Out Indefinitely

  • R. Alessandrini
    MID

    MCL Knee Ligament Injury

    Out Indefinitely

  • N. DePuy
    DEF

    DePuy is injured

    Out Indefinitely

See more MLS Injuries Right Arrow
Team Stats

5
Fouls
13
4
Shots
10
1
Corners
4
1
Offsides
1
0
Red Cards
0
1
Yellow Cards
0
1
Shots On Goal
5
41%
Possession Time
59%

Goalkeeping

LA Galaxy vs. Columbus Odds Comparison

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LA Galaxy at Columbus Team Totals

MatchupOverUnder
LA Galaxy
11-11-11
N/A
N/A
Columbus
13-15-5
N/A
N/A