The NBA regular season is back in action with an excellent slate of games this Wednesday, with a total of seven matchups on the docket scheduled for today. So, our staff of basketball betting experts dug into the latest odds and identified NBA picks for six of tonight's matchups.
Continue below for our NBA picks, odds, props, and predictions for Wednesday, January 21.
NBA Picks, Odds, Props, Predictions: Wednesday, January 21
| Game | Time (ET) | Pick |
|---|---|---|
  | 7:30 p.m. | |
  | 7:30 p.m. | |
  | 7 p.m. | |
  | 8 p.m. | |
  | 9:30 p.m. | |
  | 10 p.m. | |
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our NBA Odds page, which automatically surfaces the best lines for every game. | ||
Nets vs. Knicks
By Joe Dellera
The Knicks face off against the Nets tonight, as they try to put a halt to their 2-9 skid.
The Knicks held a players' only meeting following their latest loss, and I’m expecting a bit of a bounce back here.
Although the Nets play slow and their defense has been surprisingly effective, it still has its weak points.
While much of the conversation surrounding the Knicks is "What do we do with Karl-Anthony Towns?" I think this is a good buy spot for his points prop.
KAT has scored 28 and 37 points against Brooklyn this season and has scored 25+ in every game against them over the last few seasons. His ability to score at all levels presents issues for them.
The Nets have allowed some strong games to bigs lately, so I’ll buy into the narrative a bit here and back KAT to lock in tonight.
Pick: Karl-Anthony Towns Over 21.5 Points (-115)
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Pacers vs. Celtics
By Bet Labs
This NBA system focuses on regular season matchups where struggling road underdogs offer hidden value.
Teams on short losing streaks both straight up and against the spread often become undervalued in the market, as public sentiment turns sharply against them.
These spots tend to produce inflated lines that fail to reflect the small margins separating most NBA teams, especially when the visiting side has already been in the role of the underdog for consecutive games.
Such teams frequently respond with higher energy and focus after a string of poor performances, particularly when traveling, where distractions are limited, and motivation is heightened to end a skid.
This system capitalizes on market overreaction to recent losses, finding edges where perception diverges from reality and resilient road teams quietly bounce back to outperform expectations.
Pick: Pacers +10.5 (-110)
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Cavaliers vs. Hornets
By Kyle Murray
This is a fantastic spot for Knueppel, who obviously is going to be very trigger-happy from the three-point line.
This Cavaliers team allows the 6th-most threes per game and the most efficient three-point shooting to their opponents in terms of matchups so far this season.
I project Knueppel for 19 points in this spot, so he could easily clear the Points + Assists number on points alone.
While his assist prop has some pretty significant juice towards the over, there's some value on there as well.
Pick: Kon Knueppel Over 20.5 Points + Assists (-115)
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Hawks vs. Grizzlies
By Bet Labs
This NBA system focuses on games where visiting teams are slight underdogs in regular season play.
These matchups often feature public bias toward home favorites, especially when the spread is small and perceived as manageable.
When the road team draws little betting support and the overall betting volume is below the daily average, it signals that the market has tilted too far toward the home side.
These conditions frequently lead to inflated lines that undervalue competitive visiting teams capable of keeping games close or winning outright.
Early or midseason scheduling advantages, tighter rotations, and underdog motivation all contribute to the visitor’s ability to outperform expectations when public sentiment and pricing diverge.
Pick: Hawks +1.5 (-110)
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Thunder vs. Bucks
By Bet Labs
This NBA totals betting system is built on the idea that strong traveling teams can drive pace and scoring in matchups where the market leans too heavily toward the under.
By focusing on regular season games outside of division play, the system avoids slower rivalry environments and taps into contests that tend to be more open and less physical.
It targets overs specifically when the betting public and money trends show a clear lean toward the under, creating a contrarian opportunity where expectations are suppressed but conditions for scoring remain strong.
The away team must be early enough in its season to still carry energy and identity, and it must also be coming off a decisive win, a signal that its offense and confidence are functioning at a high level.
When these elements align, strong road teams often set the tone, push pace, and elevate scoring beyond market expectations, making the over more attractive precisely when it is being overlooked.
Pick: Over 226.5 (-110)
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Raptors vs. Kings
By Bet Labs
This NBA system targets first half moneyline opportunities where strong teams often start slow against inferior opponents.
During the regular season, underdogs with modest Pythagorean ratings face elite opponents with high win records who may be pacing themselves or conserving energy early in games.
These matchups frequently occur when the superior team is in cruise control, relying on second half adjustments rather than urgency in the opening quarters.
Meanwhile, the underdog typically plays with early intensity and effort, creating value in short term situations before talent disparity takes over.
By isolating first halves against top competition, this system leverages motivational imbalance and situational focus to identify profitable early game edges.
Pick: Kings First Half Moneyline (+125)
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