Louisville vs. Clemson Odds & Betting Predictions - February 28, 2026

Louisville at Clemson

7:00 pm • ESPN2
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Louisville at Clemson Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Louisville
20-8
-1.5
-1.5-111
o146.5-110
-130
Clemson
20-8
u145.5
+1.5-109
u146.5-110
+110
location pinSaturday 7:00 p.m.
February 28, 2026
Littlejohn ColiseumClemson
Louisville vs. Clemson Expert Picks
JMann
JMann
Last 30d: 40-28-0 (+9.3u)
CLEM +105
1u
Sean Paul
Sean Paul
Last 30d: 37-48-0 (-13.9u)
LOU -1.5-103
1u
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Prop Odds Comparison

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Line Movement Tracker

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Louisville vs. Clemson Public Betting Percentages

Away Logo

Louisville

Public

76%

Bets%

24%

Money%

NCAAB Public Betting Right Arrow

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Clemson
16-127-99-313-123-0
Louisville
13-158-85-710-100-3

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Clemson
11-175-116-610-151-2
Louisville
10-185-115-78-120-3

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Clemson
20-8N/AN/A20-50-3
Louisville
20-8N/AN/A15-50-3

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Feb 21stFSUL 65-70-8.5 LU 145.5FSU -440
Feb 19th@WAKEL 77-85-3.5 LO 140WAKE -190
Feb 14th@DUKEL 54-67+13.5 WU 134DUKE +720
Feb 12thVTL 66-76-8.5 LO 138.5VT -400
Feb 8th@CALW 77-55-4.5 WU 139.5CLEM -198

Louisville vs. Clemson Injury Updates

Louisville Injuries

  • Mikel Brown
    G

    Brown is probable with undisclosed

    Probable

Clemson Injuries

  • Zac Foster
    G

    Foster is out for season with knee

    Out for Season

  • Trent Steinour
    F/C

    Steinour is out with undisclosed

    Out

Team Stats
29-61 (48%)
Field Goals
25-55 (45%)
16-21 (76%)
Free Throws
15-20 (75%)
11-32 (34%)
3P
8-24 (33%)
37.25
Rebounds
31.86
17.5
Assists
13
11.75
Turnovers
9
7.21
Steals
6.14
3.36
Blocks
2.64
18.46
Fouls
16.29

Louisville vs. Clemson Odds Comparison

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Louisville at Clemson Team Totals

MatchupOverUnder
Louisville
20-8
N/A
N/A
Clemson
20-8
N/A
N/A