The Clemson Tigers take on the Duke Blue Devils in Charlotte, North Carolina. Tip-off is set for 9:30 p.m. EDT on ESPN2.
Duke is favored by 10.5 points on the spread with a moneyline of -600. The total is set at 133 points.
Here’s my Clemson vs. Duke prediction and college basketball picks for March 13, 2026.
Clemson vs Duke Prediction
My Pick: Duke -10.5 or Better
My Clemson vs Duke best bet is on the Blue Devils to cover. For all of your college basketball bets, be sure to find the best lines by using our live NCAAB odds page.
Clemson vs. Duke Odds
| Clemson Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+10.5 -115 | 133 -110o / -110u | +450 |
| Duke Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-10.5 -105 | 133 -110o / -110u | -600 |
- Clemson vs Duke spread: Duke -10.5
- Clemson vs Duke over/under: 133
- Clemson vs Duke moneyline: Clemson +450, Duke -600
Clemson vs Duke College Basketball Betting Preview
I project Duke as a 13.6-point favorite over Clemson on a neutral court, so I’m willing to play the Blue Devils at -10.5 or better, representing a minimum three-point difference between our projections and the market.
Is it fair to be worried about Duke in this conference tournament? Maybe. The Blue Devils are banged up, and they don’t have a huge incentive to win the tournament. Perhaps that was all shown by their effort against Florida State on Thursday.
However, I think the doubt has gone a little too far.
Duke struggled against Florida State because of some unfortunate two-way 3-point shooting variance. The Seminoles shot 11-for-28 (39%) from 3, while the Blue Devils shot 10-for-34 (29%).
Underneath that variance, Duke dominated the shot-volume battle behind a whopping 22 offensive rebounds.
ShotQuality graded that game as a 25-point Duke win based on the “quality” of shots taken and allowed (91-66).
Although Clemson has a solid frontcourt, I think the Blue Devils are a tad undervalued right now, and I’m willing to grab the nation’s best team at a discount. They beat Clemson by 13 last time these two faced off, after all.
My Pick: Duke -10.5 or Better
