Duke vs UConn Odds & Pick: NCAA Women’s Tournament Prediction

Duke vs. UConn odds have the Huskies laying eight points against the Blue Devils. The winner of this game will face either USC or Baylor with a trip to the Final Four on the line.

Let's break down the matchup and make a Duke vs. UConn pick.

Road to the Sweet 16

First round vs. No. 10 Richmond: W 72-61 (Duke -10.5, Over 125.5)
Second round vs. No. 2 Ohio State: W 75-63 (Duke +7.5, Over 131.5)

Duke is both the only team to knock off a No. 2 seed and the highest remaining seed left in the tournament. Duke's win over Ohio State was somewhat surprising if you watched the first quarter of their game.

However, Duke’s defense was unrelenting and helped spark the offense as the Blue Devils outscored the Buckeyes 43-27 in the second half.

Junior guard Reigan Richardson was incredible as she scored a game-high 28 points and shot 11-for-18 from the field.

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Road to the Sweet 16

First round vs. No. 14 Jackson State: W 86-64 (JSU +35.5, Over 135.5)
Second round vs. No. 8 Syracuse: W 72-64 (Syracuse +20, Under 144.5)

UConn returns to the Sweet 16 riding the coattails of the 2021 National Player of the Year, Paige Bueckers.

As head coach Geno Auriemma said, there may not be anyone in the country playing better than Bueckers right now. Over her past five games, Bueckers is averaging 28.6 points on 54% shooting, 9.2 rebounds and five assists per game.

UConn needs all that and more if the Huskies want to make it back to another Final Four.

Both these teams are playing their best ball in March. We’ve seen all their games go over this total and I don't expect anything different in this game.

However, I do think this game will be closer than many expect and feel a lot of late free throws down the stretch could play in a role in both hitting the over/under and covering the spread.

Pick: Over 126.5 (-110) | Play Up to 128.5 – 1 Unit
Pick: Duke +8.5 (-110) | Play Down to +7.5 – .75 Units