Louisville vs. Michigan State Odds, Picks, Predictions: How Sharps Are Betting ACC/Big Ten Challenge

Louisville vs. Michigan State Odds, Picks, Predictions: How Sharps Are Betting ACC/Big Ten Challenge article feature image
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Justin Casterline/Getty Images. Pictured: Tom Izzo

  • Louisville is an underdog on Wednesday night against Michigan State.
  • This is one of two primetime matchups to close out the ACC-Big Ten Challenge.
  • Check out where our PRO Report finds value for bettors below.

Louisville vs. Michigan State Odds

Louisville Odds +4
Michigan State Odds -4
Over/Under 137
Date Wednesday, Dec. 1
Time 7:15 p.m. ET
Channel ESPN

*Odds as of Wednesday morning.

The 2021 ACC/Big Ten Challenge wraps up on Wednesday night with five games, including Louisville vs. Michigan State and Michigan vs. North Carolina as the marquee matchups.

As of Wednesday at noon ET, our betting tools are yet to track much in the way of sharp action associated with Michigan vs. North Carolina.

However, when it comes to Louisville vs. Michigan, big bets from respected players are already influencing the line for tonight’s ACC/Big Ten Challenge matchup.

Let’s take a deeper look at the side of Louisville vs. Michigan that is attracting significant money from sharp bettors.

Louisville vs. Michigan State Sharp Betting Pick 

Louisville opened as a 5-point underdog against Michigan State, and 60% of the spread bets have landed on the Cardinals thus far.