Sweet 16 Spreads | Thursday’s Sharpest College Basketball Predictions

Sweet 16 spreads are the hot betting market in PRO, with premium picks green-lighted for more than half the NCAA Tournament games Thursday!

It was PRO Projections leading the way during the opening weekend of the NCAA Tournament. Advanced betting models predicted wrong teams favored, huge upsets and more. Thursday's sharpest college basketball predictions in PRO, meanwhile, feature more of a team effort from our various signals.

We've tracked a blend of sharp money, winning betting systems and more locking in sharp Sweet 16 spreads and picks Thursday.

For instance, the UConn vs. San Diego State betting line matches a 57% premium betting angle and edge. Both the UNC vs. Alabama and Clemson vs. Arizona spreads, meanwhile, are generating big bets from respected action.

These are Thursday's sharpest college basketball predictions for the Sweet 16, backed by pro bettors and a key, historical trend against the spread.

Sweet 16 Spreads | Thursday's Sharpest College Basketball Predictions

Clemson vs. Arizona Spread Pick

First up is a Clemson vs. Arizona pick utilizing Bet Labs' Signals. This software tracks big bets, steam moves, reverse line movement and more. We've tracked multiple bets hammering one side of Clemson vs. Arizona throughout the week.

On Monday, a sharp bettor or group