Turn your sports knowledge into winning predictions
21+ or 18+ in Certain Locations. 19+ in ON. Please Play Responsibly. Gambling Problem? Call 1-800-GAMBLER. Visit connexontario.ca or Call 1-866-531-2600 in ON.
No Code Needed

Louisville vs. Pittsburgh Odds & Betting Predictions - September 27, 2025

Louisville at Pittsburgh

4:00 pm • ESPN2

Louisville Cardinals

0-1
34
34 - 27

Pittsburgh Panthers

1-0
27

Louisville at Pittsburgh Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Louisville
0-1
-6.5
-6.5-115
o53.5-110
-155
Pittsburgh
1-0
u53.5
+6.5-105
u53.5-110
+130
location pinSaturday 4:00 p.m.
September 27, 2025
Acrisure StadiumPittsburgh
Louisville vs. Pittsburgh Expert Picks
Action Analytics
Action Analytics
Last 30d: 10-17-0 (-7.1u)
K.Johnson o31.5 Rec Yds-130
1u
C.Bell o70.5 Rec Yds-130
1u
Will Brinson
Will Brinson
Last 30d: 0-0-0 (+0.0u)
LOU -3.5-115
1u
Action Analytics
Action Analytics
Last 30d: 10-17-0 (-7.1u)
LOU -3.5-115
0.96u
Picks Office
Picks Office
Last 30d: 0-3-0 (-3.0u)
LOU -4.5+100
1u
💰🦡 Jake
💰🦡 Jake
Last 30d: 12-28-1 (+0.6u)
LOU u31.5-130
1.3u
Mjaybrod
Mjaybrod
Last 30d: 16-13-1 (+1.6u)
Under 57.5-110
1u
Dumbbell theory to the max
Doug Ziefel
Doug Ziefel
Last 30d: 182-182-8 (+3.8u)
E.Holstein o14.5 Rush Yds-115
0.5u
New Owner
New Owner
Last 30d: 0-0-0 (+0.0u)
LOU -3-110
0.91u

Louisville vs. Pittsburgh Previews & Analysis

  • Louisville vs. Pitt: Major Advantages for Cards article feature image

    Louisville vs. Pitt: Major Advantages for Cards

    Action Analytics•
    Sep 27, 2025 UTC
  • Your Week 5 NCAAF Betting Cheat Sheet article feature image

    Your Week 5 NCAAF Betting Cheat Sheet

    Pete Ruden•
    Sep 27, 2025 UTC
See more NCAAF Coverage Right Arrow

Prop Odds Comparison

Right Arrow
Right Arrow

No props found

Line Movement Tracker

Right Arrow
Right Arrow

Louisville vs. Pittsburgh Public Betting Percentages

Away Logo

Louisville

Public

Home Logo

Pittsburgh

51%

Bets%

49%

Money%

NCAAF Public Betting Right Arrow

Betting Trends

  • Pittsburgh are 1-0 in their last 5 games.
  • Pittsburgh are 1-0 in their last 5 games against the spread
  • The totals have gone OVER in 1 of Pittsburgh' last 1 games
  • The totals have gone OVER in 1 of Pittsburgh' 1 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Pittsburgh		1-01-0N/A1-0N/A
Louisville		1-0N/AN/AN/A1-0

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Pittsburgh		1-01-0N/A1-0N/A
Louisville		1-0N/AN/AN/A1-0

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Pittsburgh		1-0N/AN/A1-0N/A
Louisville		0-1N/AN/AN/A0-1

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Sep 13th@WVUL 24-31-7 LU 55.5WVU -275
Sep 6thCMUW 45-17-21.5 WO 48PITT -2000
Aug 30thDUQW 61-9-40.5 WO 58.5-
Dec 26th@TOLL 46-48-6.5 LO 48.5TOL -238
Nov 30th@BCL 23-34+3.5 LO 50.5BC +140
Team Stats

Total

392
Total Yards
339
85
Total Plays
55
4.6117647058823525
Yards Per Play
6.163636363636364

Passing

339
YDS
259
33/51
Comps/Atts
17/32
6.647058823529412
YPA
8.09375
3/1
TDs/INTs
2/3
2/20
Sacks/Yards
2/8

Rushing

53
Rush Yards
80
34
Attempts
23
1.5588235294117647
YPC
3.4782608695652173
1
TDs
0

Turnovers

0
Fumbles Lost
2
1
Interceptions
3

Efficiency

4/4 100%
Redzone
2/3 66.67%
9/19 0%
3rd Down
1/10 0%
0/0 0%
4th Down
1/4 0%

First Downs

23
Total
14
16
Pass
9
6
Rush
3
1
Penalty
2

Misc

9/92
Penalties/Yards
6/38

Louisville vs. Pittsburgh Odds Comparison

Right Arrow

Could not load odds

See more NCAAF Odds Right Arrow

Louisville at Pittsburgh Team Totals

MatchupOverUnder
Louisville
0-1
N/A
N/A
Pittsburgh
1-0
N/A
N/A