Louisville vs. Pittsburgh Odds & Betting Predictions - September 27, 2025

Louisville at Pittsburgh

4:00 pm • ESPN2

Louisville Cardinals

@

Pittsburgh Panthers

MatchupOpenSpreadTotalMoneyline
Louisville 3-0	-6.5	-6.5-115	o53.5-110	-245
Pittsburgh 2-1	u53.5	+6.5-105	u53.5-110	+198

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Saturday 4:00 p.m.

September 27, 2025

Acrisure StadiumPittsburgh

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72°Fahrenheit

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0%Rain

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5Wind

LOU -3-110

1u

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NCAAF Public Betting

Pittsburgh are 2-1 in their last 5 games.
Pittsburgh are 2-1 in their last 5 games against the spread
Pittsburgh are 0-1 in their road games against the spread
The totals have gone OVER in 2 of Pittsburgh' last 3 games
The totals have gone OVER in 2 of Pittsburgh' 2 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Pittsburgh	2-1	2-0	0-1	1-1	N/A
Louisville	0-3	0-3	N/A	0-3	N/A

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Pittsburgh	2-1	2-0	0-1	1-1	N/A
Louisville	2-1	2-1	N/A	2-1	N/A

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Pittsburgh	2-1	N/A	N/A	1-1	N/A
Louisville	3-0	N/A	N/A	3-0	N/A

date	opponent	score	spread	over/under	moneyline
Sep 13th	@WVU	L 24-31	-7 L	U 55.5	WVU -275
Sep 6th	CMU	W 45-17	-21.5 W	O 48	PITT -2000
Aug 30th	DUQ	W 61-9	-40.5 W	O 58.5	-
Dec 26th	@TOL	L 46-48	-6.5 L	O 48.5	TOL -238
Nov 30th	@BC	L 23-34	+3.5 L	O 50.5	BC +140

Total

Passing

777

YDS

945

62/93

Comps/Atts

69/108

8.35

YPA

8.75

3/3

TDs/INTs

10/3

6/43

Sacks/Yards

8/57

Rushing

468

Rush Yards

328

89

Attempts

87

5.26

YPC

3.77

8

TDs

5

Turnovers

Fumbles Lost

3

Interceptions

3

Efficiency

9/10 90%

Redzone

16/18 88.9%

15/34 0%

3rd Down

15/40 0%

1/2 0%

4th Down

3/6 0%

First Downs

60

Total

58

30

Pass

32

23

Rush

17

7

Penalty

9

Misc

/

Penalties/Yards

/

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MatchupOverUnder
Louisville 3-0	N/A	N/A
Pittsburgh 2-1	N/A	N/A