The California Golden Bears take on the Stanford Cardinal in Stanford, Calif. Kickoff is set for 7:30 p.m. ET on ACC Network.
Cal is favored by 3 points on the spread with a moneyline of -150. Stanford, meanwhile, comes in as a +3 underdog and is +125 on the moneyline to pull off the upset. The over/under sits at 47.5 total points.
Here’s my Cal vs. Stanford prediction and college football picks for Saturday, November 22.
Cal vs Stanford Prediction
- Cal vs. Stanford Pick: PICK
My Stanford vs. Cal best bet is on PICK. Find the best line available on our live NCAAF odds page.
Cal vs Stanford Odds
| California Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-3 -105 | 47.5 -105o / -115u | -150 |
| Stanford Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+3 -115 | 47.5 -105o / -115u | +125 |
- Cal vs Stanford Spread: Cal -3, Stanford +3
- Cal vs Stanford Over/Under: 47.5 Points
- Cal vs Stanford Moneyline: Cal -150, Stanford +125
Cal vs Stanford College Football Betting Preview
Saturday's Cal vs. Stanford ACC game fits a historically profitable betting system called "Road Streak" from our Bet Labs database.
In regular-season college football conference play, teams from power conferences — in this case, the ACC — that are in the middle of multi-game road trips often perform better than expected against the spread.
These stretches test a team’s endurance and focus, but they also build rhythm, cohesion and a sense of purpose that single road games don't.
Because oddsmakers and bettors tend to overvalue home-field advantages and undervalue teams in extended travel sequences, disciplined and motivated road squads can capitalize on inflated lines.
In conference matchups — where familiarity with opponents and schemes reduces volatility — these teams are better equipped to execute within controlled game environments, especially when totals are modest and favor structured play rather than high-scoring chaos.
This system boasts an all-time record of 398-300-5, good for a winning percentage of 57% and an ROI of 10.7%. While the system hasn't been quite as profitable in 2025, it's still cashing at a 55% clip.
Cal vs Stanford Pick, Betting Analysis
We're going to back the team with the better quarterback here.
Cal's Jaron-Keawe Sagapolutele ranks fourth in the ACC with 2,518 yards passing and has thrown for 13 touchdowns with nine interceptions.
JKS is also coming off one of his best games of the season, when he threw for 323 yards, two touchdowns and no picks in an overtime win over a ranked Louisville team.
Meanwhile, Stanford has recently made a quarterback change after signal-caller Ben Gulbranson got benched following a three-interception performance against Pitt. Gulbranson struggled all season, tossing more interceptions (10) than touchdowns (9).
They recently went to freshman Elijah Brown, who has been solid but not spectacular.
For what it's worth, Stanford ranks dead last in the ACC in scoring offense and second-to-last in total offense.
Given the system at play and the matchup between these quarterbacks, we'll take the Golden Bears to cover the short spread on Saturday night.
Pick: Cal -3
Cal vs Stanford Betting Trends
