The Kentucky Wildcats take on the Vanderbilt Commodores in Nashville, Tennessee. Kickoff is set for 3:30 p.m. EST on ESPN.
Vanderbilt is favored by 8.5 points on the spread with a moneyline of -355. The total is set at 54.5 points.
Here’s my Kentucky vs. Vanderbilt prediction and college football picks for Saturday, November 22, 2025.
Kentucky vs Vanderbilt Prediction
- Kentucky vs. Vanderbilt Pick: Kentucky +10 or Better
Kentucky vs Vanderbilt Odds
| Wildcats Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+8.5 -108 | 54.5 -105o / -115u | +280 |
| Commodores Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-8.5 -112 | 54.5 -105o / -115u | -355 |
- Kentucky vs Vanderbilt point spread: Vanderbilt -8.5
- Kentucky vs Vanderbilt over/under: 54.5
- Kentucky vs Vanderbilt moneyline: Kentucky +280, Vanderbilt -355
Kentucky vs Vanderbilt Pick
I project Vanderbilt as a 10-point favorite.
But I think this game is going to be a brawl.
Kentucky won’t allow any explosives, and Vanderbilt isn’t trying to create explosives.
Instead, the Commodores are going to be extremely methodical on offense.
The key to this game is whether Kentucky can defend the counter and man rush concepts that Diego Pavia and the Commodores run. The Wildcats absolutely can do that.
This game is a grind, and you should take as many points as you can get. I would love +10 with Kentucky, but I need double-digits to back the 'Cats.
Pick: Kentucky +10 or Better
