The Louisiana Ragin' Cajuns take on the Missouri Tigers in Columbia, MO. Kickoff is set for 4 p.m. ET on SEC Network+.
Missouri is favored by -27.5 points on the spread with a moneyline of -5000. The total is set at 48.5 points.
Here’s my Louisiana vs. Missouri predictions and college football picks for Saturday, September 13, 2025.
Louisiana vs Missouri Prediction
- Louisiana vs. Missouri Pick: Over 48.5
My Missouri vs. Louisiana best bet is on the over. Find the best line available on our live NCAAF odds page.
Louisiana vs Missouri Odds
| Louisiana Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+27.5 -115 | 48.5 -110o / -110u | +1800 |
| Missouri Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-27.5 -105 | 48.5 -110o / -110u | -5000 |
- Louisiana vs Missouri point spread: Missouri -27.5
- Louisiana vs Missouri over/under: 48.5 points
- Louisiana vs Missouri moneyline: Louisiana +1800, Missouri -5000
Louisiana vs Missouri Pick, Betting Analysis
The Missouri offense has been booming through two weeks, as its scored 103 points thanks to senior quarterback Beau Pribula tossing five touchdowns to zero interceptions.
The competition hasn't exactly been stiff (Central Arkansas, Kansas), but nonetheless, it's still impressive for a team that was projected to finish 12th in the SEC Preseason Poll.
Our over pick makes sense on the field, but it also makes sense when you look at the system that's lighting up.
Evan Abrams' "Weather NCAAF Overs" is +$5,037 with a 13.7% return on investment (ROI) since its inception.
And this game is one of its marks.
In non-conference games played in hot (85-106°F), low-wind (0-10 mph) conditions, offenses thrive and pace increases. This system backs the over when weather supports high-tempo play and defenses are less likely to dominate due to early-season conditioning.
In early-season non-conference college football games played in extreme heat with minimal wind, offensive production often flourishes. High temperatures can slow defenses and lead to more missed tackles, while calm conditions allow passing attacks to operate without disruption.
Teams are still developing defensive cohesion, and the pace of play often favors quick scoring drives.
When the closing total is modest, the environment creates an opportunity for the over to hit as both sides exploit favorable weather to push the tempo and generate sustained offensive success.
This matches up nicely with this affair, but one other system is also lighting up on this game: Evan Abrams' "Big Spread, Low Total, Over." It has a similar return on investment to the system we mentioned previously, making this a nice value bet for Week 3.
Pick: Over 48.5
