The Vanderbilt Commodores take on the South Carolina Gamecocks in Columbia, South Carolina. Kickoff is set for 7:45 p.m. ET on SEC Network.
South Carolina is favored by 4.5 points on the spread with a moneyline of -190. The total is set at 48.5 points.
Here’s my Vanderbilt vs. South Carolina prediction and college football picks for Saturday, September 13.


Vanderbilt vs South Carolina Prediction
- Vanderbilt vs. South Carolina Pick: Vanderbilt +4.5 Or Better
My South Carolina vs. Vanderbilt best bet is on the Commodores to cover. Find the best line available on our live NCAAF odds page.
Vanderbilt vs South Carolina Odds
Vanderbilt Odds | ||
---|---|---|
Spread | Total | Moneyline |
+4.5 -110 | 48.5 -110o / -110u | +155 |
S. Carolina Odds | ||
---|---|---|
Spread | Total | Moneyline |
-4.5 -110 | 48.5 -110o / -110u | -190 |
- Vanderbilt vs South Carolina point spread: South Carolina -4.5
- Vanderbilt vs South Carolina over/under: 48.5 points
- Vanderbilt vs South Carolina moneyline: Vanderbilt +155, South Carolina -190


Vanderbilt vs South Carolina Pick, Betting Analysis
Early in the college football season, bettors are starved for data points, especially in this new era with heavy roster turnover.
Well, you can't ask for better data points when it comes to this matchup, as both teams have played Virginia Tech.
In South Carolina's case, the Gamecocks played Virginia Tech to a stalemate on a neutral field but pulled away late after an 80-yard punt return touchdown.
Conversely, Vanderbilt went into Blacksburg and dominated the Hokies, out-gaining them by 242 total yards (490 to 248) with an 8.6-to-4.1 yards per play edge.
Meanwhile, the Gamecocks were actually out-gained (336 to 328).
And it's not like South Carolina followed that up with a super impressive performance last week against South Carolina State.
The 42.5-point FCS underdog actually finished with more yards (270 to 253) and almost the same yards per play (4.5 to 4.4).
LaNorris Sellers finished just 11-for-19 passing for 1,28 yards, and the rushing attack was again non-existent.
The Gamecocks have issues on offense, and their defense lost a plethora of talent to the NFL.
Even the special teams (where Vanderbilt should hold an edge) lost all of its key pieces.
Contrary to their respective rankings and public perception, I don't think there's much separating these teams at all. Give me Diego Pavia and the points.
For what it's worth, Vanderbilt is 8-2 ATS as an underdog with Pavia under center, including 4-0 ATS on the road. The Commodores have pulled outright upsets in five of those games.
Pick: Vanderbilt +4.5 Or Better