Thursday Night Football opens NFL Week 6 with Seahawks vs. Broncos at 8:15 p.m. ET on Prime Video, and new bettors can lock in one of the top offers on the board with the bet365 bonus code.
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Seahawks vs. Broncos Prediction: Our Pick for Thursday Night Football
Seattle travels to Denver on short rest after a shootout loss to the 49ers. Denver enters at 3-2 as well, coming off a road win over the Chargers. Both defenses have shown real flaws over five weeks, and the short week adds uncertainty to this week's NFL odds.
Current lines for Seahawks vs. Broncos:
- Moneyline: Seahawks -144 | Broncos +122
- Spread: Seahawks -2.5 (-114) | Broncos +2.5 (-106)
- Total: Over 40.5 (-114) | Under 40.5 (-106)
Action Network's Pablo Planovsky backs Seattle to cover, and this Seahawks vs. Broncos prediction follows his read. Sam Darnold and Jaxon Smith-Njigba carry a passing attack that keeps pace against elite offenses, while Denver's J.K. Dobbins-led ground game leans on efficiency over explosive plays. A short-week road trip to altitude creates unpredictable margins, but Seattle's overall body of work through five games supports laying the points.
Bettors who prefer trading markets over traditional lines can also weigh this NFL prediction market vs. sportsbook breakdown before wagering.
Thursday also stacks two more postseason games for fans juggling multiple screens. ALCS Game 3 between the Rays and Guardians starts at 6 p.m. ET on TBS/truTV, and NLCS Game 4 between the Brewers and Dodgers follows at 9 p.m. ET on FOX/FS1.
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