College Basketball Predictions Today | 13 Best College Basketball Picks Today (NCAAB Predictions for November 6)

The Polymarket promo code (ACTION) is perfect to use on Friday's college hoops games, and these college basketball predictions today round up our 13 best college basketball picks today from the live Polymarket board.

• The games we're covering range from a national championship rematch between UConn and Michigan at TD Garden to the first Missouri vs Saint Louis meeting in 25 years.
• Our 13 picks include nine spread plays, two totals, and two moneylines, and Polymarket's lines differ from ESPN's DraftKings numbers in six of the games.

Here is our full picks table from the best prediction markets before we break down every game, with our NCAAB predictions listed in game order.

Read our dedicated Polymarket review to learn more, or check out more prediction market promo codes for other platforms.

College Basketball Predictions Today: Our Top Polymarket Picks for November 6

Every pick below is a real trade we'd make on Polymarket, part of our best college basketball picks today for the NCAAB games we're covering. Not sure where to trade? Start with the best prediction market apps.

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These college basketball predictions today are built around Polymarket prices as they stand right now, and our NCAAB predictions can change if lines move before tip.

Eastern Washington vs Oregon Prediction

Oregon is 1-0 and hosts Eastern Washington, which is 0-1, at Matthew Knight Arena in Eugene.

It is a Big Ten host against a Big Sky visitor, and Polymarket and ESPN agree on the 16.5-point spread. Polymarket's total sits at 152.5, two points above the 150.5 on ESPN's DraftKings line.

Best Spread Pick Today: Oregon -16.5

Oregon is a heavy home favorite, and this is a straight cover bet on a number both markets share.

The price sits at 50¢, essentially a coin flip, so the case is simply the Ducks' home-court edge against a team that dropped its opener.

At a 50¢ average price, a $100 buy works out to roughly 200 shares, and the ticket shows a return of $193.28.

• If Oregon wins by 17 or more: Return of $193.28.
• If not: the $100 stake is a total loss.

That's just under a 2x return on a number priced close to a coin flip.

Valparaiso vs Purdue Prediction

Purdue opened its season with a 78-72 loss to No. 15 Gonzaga in Las Vegas, just the second season-opening loss of Matt Painter's 22 years in West Lafayette.

Valparaiso is 1-0 after beating Western Illinois, and the Beacons visit Mackey Arena for the Boilermakers' home opener. Purdue leads the all-time series 17-1.

Best Spread Pick Today: Purdue -19.5

Purdue should come out sharp in front of its home crowd after a rare opening loss.

KenPom ranks Purdue No. 26 and Valparaiso No. 140, and the Boilermakers have won 17 of the 18 meetings. Polymarket's 19.5-point spread also matches ESPN's.

On the ticket itself, a $100 buy at a 51¢ average price comes to roughly 196 shares, with a stated return of $189.62.

• If Purdue wins by 20 or more: Return of $189.62.
• If not: the $100 stake is a total loss.

A return of roughly 1.9x on a near coin-flip price.

Youngstown State vs Ohio State Prediction

Youngstown State is 0-6 all-time against Ohio State, and every one of those meetings was played in Columbus.

The most recent was an 81-47 Buckeyes win on Nov. 11, 2024, and the Penguins return to Schottenstein Center under coach Ethan Faulkner.

Best Spread Pick Today: Ohio State -25.5

That 34-point result in 2024 is the freshest look at how this matchup can go.

Polymarket's 25.5-point spread matches ESPN's, which gives this price a clean comparison point. At 51¢, the market treats the cover as close to a coin flip.

At a 51¢ average price, a $100 buy works out to roughly 196 shares, and the ticket shows a return of $189.62.

• If Ohio State wins by 26 or more: Return of $189.62.
• If not: the $100 stake is a total loss.

A return of roughly 1.9x for backing the Buckeyes to win big at home.

Loyola Maryland vs Mount St. Mary's Prediction

Mount St. Mary's hosts Loyola Maryland at Knott Arena in Emmitsburg, a Maryland matchup between a MAAC home team and a Patriot League visitor.

The Mountaineers opened their season Nov. 2 at Xavier, and this is their first regular-season home game under coach Donny Lind.

Best Spread Pick Today: Loyola Maryland +5.5

Both markets have Mount St. Mary's as a 5.5-point favorite, so this is a straight call on the number.

In a low-information early-season game between two mid-majors, a 5.5-point cushion is a lot to give up, and that is what the 51¢ No price is buying.

Buying the No side at a 51¢ average price, a $100 buy works out to roughly 196 shares, and the ticket shows a return of $189.62.

• If Loyola Maryland wins or loses by five or fewer: Return of $189.62.
• If not: the $100 stake is a total loss.

A return of roughly 1.9x with the points in your pocket.

East Tennessee State vs NC State Prediction

NC State is in the Justin Gainey era, and the new coach opened with an 83-64 win over Campbell on Nov. 2 at the Lenovo Center.

East Tennessee State is 0-1 and visits Raleigh as a 16.5-point underdog, a number Polymarket and ESPN share.

Best Spread Pick Today: East Tennessee State +16.5

NC State's 19-point opening win sits just above this number, which is part of why the market treats the spread as near even.

A first-year staff with a new roster can look uneven in game two, and 16.5 points is plenty of cushion for a visitor. The No side at 48¢ also pays slightly better than a coin flip.

Buying the No side at a 48¢ average price, a $100 buy works out to roughly 208 shares, and the ticket shows a return of $201.06.

• If East Tennessee State wins or loses by 16 or fewer: Return of $201.06.
• If not: the $100 stake is a total loss.

A return just over 2x, a touch better than a standard coin flip.

Wofford vs North Carolina Prediction

North Carolina is in the Michael Malone era, and the new coach won his debut 80-72 over Western Carolina.

Rebounding has been the early talking point heading into this one, according to a game preview. Polymarket has UNC laying 24.5 points, two more than the 22.5 on ESPN's DraftKings line, though both markets share the 156.5 total.

Best Total Pick Today: Under 156.5

UNC's opener finished with 152 combined points, below this number.

A new staff and a roster full of new faces can slow things down while rotations settle, and the Under at 51¢ is priced as a true coin flip.

Buying the No side at a 51¢ average price, a $100 buy works out to roughly 196 shares, and the ticket shows a return of $189.62.

• If the game finishes with 156 or fewer total points: Return of $189.62.
• If not: the $100 stake is a total loss.

A return of roughly 1.9x on a total both markets agree on.

American vs Clemson Prediction

Clemson opened the season with an 85-72 win over Stetson and is 1-0 heading into this home game against American.

American is 0-1 and visits Littlejohn Coliseum, where the game airs on ACC Network Extra.

Best Spread Pick Today: Clemson -18.5

Clemson put up 85 points in its opener, and the Tigers are at home against a 0-1 opponent.

The catch is the number. Polymarket's 18.5 is two points steeper than the 16.5 on ESPN's DraftKings line, so this is a harder cover than that line would suggest.

At a 54.62¢ average price, a $100 buy works out to roughly 183 shares, and the ticket shows a return of $177.51. Polymarket's board shows 51% on the Yes side, but the ticket fills at that higher average price, so we use it in the table.

• If Clemson wins by 19 or more: Return of $177.51.
• If not: the $100 stake is a total loss.

A return of about 1.8x, with the extra price reflecting the steeper line.

Saint Louis vs Missouri Prediction

Missouri and Saint Louis meet for the first time in 25 years in the opener of a three-game series at Enterprise Center in St. Louis.

SLU went 29-6 last season and reached the second round of the NCAA Tournament under Josh Schertz, while Mizzou has played at Enterprise Center every year since 1994 in the Braggin' Rights game against Illinois.

Best Moneyline Pick Today: Missouri

Missouri's 56% moneyline price makes it a modest favorite on a neutral floor the Tigers know well.

Polymarket's spread has Missouri at -1.5, a point shorter than the -2.5 on ESPN's DraftKings line, so the market reads this as slightly closer than the sportsbook does.

On the ticket itself, a $100 buy at a 56¢ average price comes to roughly 179 shares, with a stated return of $173.26.

• If Missouri wins outright: Return of $173.26.
• If not: the $100 stake is a total loss.

A return of about 1.7x on the favorite's side of a close game.

Indiana State vs Ball State Prediction

Ball State hosts in-state rival Indiana State at Worthen Arena in Muncie, a Mid-American vs Missouri Valley matchup.

Polymarket and ESPN agree on both numbers here, with Ball State a 2.5-point favorite and the total at 147.5.

Best Total Pick Today: Over 147.5

Neither team has much of a 2026-27 sample yet, so a total this early leans on last season and preseason reads.

With both markets sharing 147.5, the Over at 52¢ is a clean read on the number, priced a hair above even.

At a 52¢ average price, a $100 buy works out to roughly 192 shares, and the ticket shows a return of $186.09.

• If the game finishes with 148 or more total points: Return of $186.09.
• If not: the $100 stake is a total loss.

A return of roughly 1.9x for a price right around even.

Eastern Michigan vs Xavier Prediction

Xavier is 1-0 and brings a size advantage into Cintas Center, with 10 players taller than 6-foot-6 against three for Eastern Michigan, per a game preview.

The Musketeers return after a 15-18 season, and ESPN's DraftKings line has them at -23.5 while Polymarket's spread sits at 22.5.

Best Spread Pick Today: Eastern Michigan +22.5

A 22.5-point spread is a big ask for a team still integrating transfers, even one with Xavier's size.

The honest caveat is that DraftKings' number is a point more generous to the underdog than Polymarket's, so shopping the line matters here.

Buying the No side at a 53.15¢ average price, a $100 buy works out to roughly 188 shares, and the ticket shows a return of $182.23. Polymarket's board shows 52% on the No side, but the ticket fills at that higher average price, so we use it in the table.

• If Eastern Michigan wins or loses by 22 or fewer: Return of $182.23.
• If not: the $100 stake is a total loss.

A return of about 1.8x for an underdog price a point above even.

Florida Atlantic vs Wright State Prediction

Both teams are 1-0 heading into the Nutter Center in Fairborn, Ohio, where the game streams on ESPN+.

Wright State is a 3.5-point favorite on both Polymarket and ESPN, so the spread and moneyline tell a consistent story.

Best Moneyline Pick Today: Florida Atlantic

A 3.5-point spread means the market sees this as roughly a one-possession game.

At 39% on the moneyline, Florida Atlantic is priced as a real underdog rather than a long shot, and the moneyline is where the bigger payout lives.

At a 39¢ average price, a $100 buy works out to roughly 256 shares, and the ticket shows a return of $245.97.

• If Florida Atlantic wins outright: Return of $245.97.
• If not: the $100 stake is a total loss.

A return of nearly 2.5x, the largest multiple among our 13 picks.

Delaware vs Wisconsin Prediction

Wisconsin and Delaware have never met, and the Blue Hens visit the Kohl Center for the Badgers' second game of the season.

Delaware is coached by Martin Ingelsby, and Polymarket and ESPN both have Wisconsin laying 24.5 points.

Best Spread Pick Today: Wisconsin -24.5

Wisconsin is a home Big Ten favorite against a Conference USA visitor, in a game with no head-to-head history to lean on.

The lines match across sources at 24.5, so the 52¢ price is a clean read on the cover.

On the ticket itself, a $100 buy at a 52¢ average price comes to roughly 192 shares, with a stated return of $186.09.

• If Wisconsin wins by 25 or more: Return of $186.09.
• If not: the $100 stake is a total loss.

A return of roughly 1.9x for a price a hair above even.

UConn vs Michigan Prediction

This is a rematch of the 2026 national championship game, which Michigan won 69-63, played at TD Garden in Boston as part of the TNT Sports Hall of Fame Series.

ESPN lists UConn at No. 4 and Michigan at No. 16, and Michigan leads the all-time series 3-2.

Best Spread Pick Today: Michigan +7.5

Last April's final was a six-point game, and Polymarket has UConn as a 7.5-point favorite, the same number as ESPN's.

Taking Michigan and the points wins if the Wolverines win outright or lose by seven or fewer, which would cover the six-point margin from the title game. Polymarket's total is 142.5 against 141.5 on ESPN, but this pick is about the spread.

Buying the No side at a 51¢ average price, a $100 buy works out to roughly 196 shares, and the ticket shows a return of $189.62.

• If Michigan wins or loses by seven or fewer: Return of $189.62.
• If not: the $100 stake is a total loss.

A return of roughly 1.9x with a full 7.5 points of cushion.

What's Moving the Market: NCAAB Predictions on Polymarket

Prediction markets and prices can move for many reasons, and Polymarket's own movement arrows show the Over side marked lower on every totals board we pulled for these college basketball predictions today.

The biggest moneyline swings sit in the closest games. Missouri's price is marked down 14 points to 56% while Saint Louis is marked up 9 to 46%, Ball State is marked down 14 to 57%, and Florida Atlantic is marked down 15 to 39%. We can't say what drove any of those moves.

Line shopping matters too. Polymarket and ESPN's DraftKings numbers differ in six of our 13 games, including UNC at -24.5 against -22.5, Clemson at -18.5 against -16.5, and Oregon's total at 152.5 against 150.5. Compare any of our NCAAB predictions against the latest NCAAB odds before you trade.

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• Read a comprehensive Polymarket review to understand how this exchange operates.
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Final Thoughts: College Basketball Predictions Today

Friday's college basketball predictions today are built around spreads, with Oregon, Purdue, and Ohio State as the big favorites we back to cover and Michigan, Eastern Michigan, and East Tennessee State as the underdogs we like with the points.

Missouri and Florida Atlantic round out our best college basketball picks today on the moneyline, while the Under in UNC's game and the Over in Ball State's game give us one total on each side.

That wraps our NCAAB predictions for the games we're covering. For a longer view, check the latest NCAAB futures.

Polymarket Promo Code FAQs

What are the best college basketball picks today?

Our 13 best college basketball picks today include nine spreads, two totals, and two moneylines, headlined by Michigan +7.5 in the UConn title-game rematch and a Missouri moneyline in the first Mizzou vs SLU game in 25 years.

Where can I find college basketball predictions today?

This page rounds up college basketball predictions today for 13 games using live Polymarket prices, with a summary table at the top and a full breakdown for every game.

What are the best NCAAB predictions for November 6?

Among our NCAAB predictions, Oregon -16.5, Purdue -19.5, and Ohio State -25.5 are the favorites we back to cover, while Michigan +7.5 and Eastern Michigan +22.5 are two of the underdog spreads we like.

How do I use the Polymarket promo code?

Create an account, make a qualifying deposit, and enter the Polymarket promo code during sign-up to unlock the trading bonus, subject to the terms and conditions.

How do Polymarket college basketball contracts resolve?

Spread and total contracts resolve Yes if the stated condition is met in the final score and No if it isn't, while moneyline contracts resolve on which team wins. Each share pays 1 dollar when your side wins and nothing when it doesn't.

Why are Polymarket's lines different from ESPN's?

Polymarket's spreads and totals are set by traders in an order book rather than by a sportsbook, so they can sit a point or two away from the DraftKings lines shown on ESPN. In this piece, six of the 13 games have at least one line that differs.

What does the Return column in the picks table mean?

It shows what a 100-dollar trade returns if the pick wins, including your original stake, taken from the ticket's To Win figure. Tables labeled Est. Return use an estimate based on the listed price instead.

Does this cover every college basketball game on Friday?

No. These 13 games are the ones we're covering, and Polymarket has markets for many more college basketball games on Friday.