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Cardinals vs. Chiefs Odds & Betting Predictions - November 22, 2026

Cardinals at Chiefs

6:00 pm • CBS

Arizona Cardinals

3-5
@

Kansas City Chiefs

5-2

Cardinals at Chiefs Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Cardinals
3-5
N/A
N/A
N/A
Chiefs
5-2
N/A
N/A
N/A
location pinSunday 6:00 p.m.
November 22, 2026
Arrowhead StadiumKansas City

Cardinals vs. Chiefs Props

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Cardinals vs. Chiefs Public Betting Percentages

Away Logo

Cardinals

Public

Home Logo

Chiefs

50%

Bets%

50%

Money%

NFL Public Betting Right Arrow

Betting Trends

  • Chiefs are 4-1 in their last 5 games.
  • Chiefs are 3-2 in their last 5 games against the spread
  • Chiefs are 1-3 in their road games against the spread
  • The totals have gone OVER in 2 of Chiefs' last 5 games
  • The totals have gone OVER in 1 of Chiefs' 3 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Chiefs		3-42-11-33-20-2
Cardinals		4-40-34-10-14-3

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Chiefs		3-41-22-22-31-1
Cardinals		5-32-13-21-04-3

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Chiefs		5-2N/AN/A5-00-2
Cardinals		3-5N/AN/A0-13-4

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Nov 1st@DENL 24-28-0.5 LO 42DEN -109
Oct 26th@SEAL 3-20+3 LU 43SEA +136
Oct 18thLACW 22-6-7.5 WU 41.5KC -425
Oct 4th@LVW 30-27-5 LO 47.5KC -235
Sep 27th@MIAW 24-10-9.5 WU 45.5KC -600

Chiefs vs. Cardinals Injury Updates

Chiefs Injuries

  • Tyquan Thornton
    WR

    Thornton is out with ankle

    Out

  • Brashard Smith
    RB

    Smith is out with hamstring

    Out

Cardinals Injuries

  • Kendrick Bourne
    WR

    Bourne is out with ankle

    Out

  • James Conner
    RB

    Conner is out with foot

    Out

  • Hunter Long
    TE

    Long is out with knee

    Out

  • Bam Knight
    RB

    Knight is doubtful with concussion

    Doubtful

  • Michael Wilson
    WR

    Wilson is questionable with ribs

    Questionable

  • Jalen Brooks
    WR

    Brooks is out with unknown

    Out

  • Jeremiyah Love
    RB

    Love is doubtful with ankle

    Doubtful

See more NFL Injuries Right Arrow
Player Stats
  • passing yards
    Patrick Mahomes logo
    Patrick Mahomes
    1795
    pyds
  • passing touchdowns
    Patrick Mahomes logo
    Patrick Mahomes
    12
    ptd
  • rushing yards
    Kenneth Walker logo
    Kenneth Walker
    770
    ryds
  • rushing touchdowns
    Kenneth Walker logo
    Kenneth Walker
    6
    rtd
Depth Charts
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Starter2ND3RD4TH
QBPatrick MahomesJustin FieldsGarrett Nussmeier
RBKenneth WalkerBrashard SmithEmmett JohnsonJaydn Ott
WRRashee RiceCyrus AllenNikko Remigio
TETravis KelceNoah GrayJared WileyJake Briningstool
LTJosh SimmonsEthan Driskell
LGKingsley Suamataia
CCreed HumphreyHunter NourzadPete Nygra
RGTrey SmithMike Caliendo
RTJaylon MooreKahlil Benson
LDEGeorge KarlaftisR Mason ThomasEmmanuel Ogbah
RDEAshton GillotteFelix Anudike-UzomahTyreke Smith
WLBDrue TranquillJeffrey BassaCole Christiansen
MLBNick BoltonCooper McDonaldJack Cochrane
LCBNohl WilliamsKristian FultonMelvin SmithD'Arco Perkins-McAllister
SSChamarri ConnerJaden HicksDeShon Singleton
FSAlohi GilmanXavier Nwankpa
RCBMansoor DelaneL'Jarius Sneed
PMatt Araiza
HMatt Araiza
PRNikko RemigioBrashard SmithCyrus Allen
KRNikko RemigioBrashard SmithTyquan ThorntonCyrus Allen
LSJames Winchester
RWRXavier WorthyJalen RoyalsJimmy Holiday
KHarrison Butker
NTKhyiris TongaOmarr Norman-LottMarcus Harris
NBChris Roland-WallaceJadon CanadyKader Kohou
DTChris JonesPeter Woods
LWRTyquan ThorntonAndrew ArmstrongOmari Evans
Team Stats

Passing

1790
YDS
1743
211/329
Comps/Atts
154/232
5.818
YPA
7.737
13/7
TDs/INTs
12/4
20/124
Sacks/Yards
9/52

Rushing

874
Rush Yards
939
208
Attempts
185
4.202
YPC
5.076
4
TDs
7

Turnovers

Fumbles Lost
7
Interceptions
4

Efficiency

15/33 45.46%
Redzone
15/26 57.69%
48/124 0%
3rd Down
34/85 0%
8/13 0%
4th Down
7/13 0%

First Downs

169
Total
139
104
Pass
78
45
Rush
52
20
Penalty
9

Misc

/
Penalties/Yards
/
Possession

Cardinals vs. Chiefs Odds Comparison

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Cardinals at Chiefs Team Totals

MatchupOverUnder
Cardinals
3-5
N/A
N/A
Chiefs
5-2
N/A
N/A