Bills at Saints NFL Odds, Picks & Predictions: Thanksgiving’s Biggest Betting Model Edge

Bills at Saints NFL Odds, Picks & Predictions: Thanksgiving’s Biggest Betting Model Edge article feature image
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Jonathan Bachman/Getty Images. Pictured: Saints coach Sean Payton

Bills at Saints Odds

Bills Odds -6.5
Saints Odds +6.5
Over/Under 45
Date Thursday, Nov. 25
Time 8:20 p.m. ET
TV NBC

*Odds as of Wednesday afternoon

The NFL’s Thanksgiving night game typically splits viewers into two different groups.

First, we have those afforded enough peace and quiet to take a stomach-filled Thanksgiving afternoon nap, meaning they’re well-rested and ready to sweat the entire Buffalo Bills at New Orleans Saints Thursday night matchup.

This is not me.

Then, we have those with no time to rest during the chaos of Thanksgiving Day, making it very unlikely they’ll make it through Bills at Saints in its entirety.

This is me, except I’ll be battling to see halftime.

However, I’m smart enough (barely) to know this, and we don’t necessarily need to watch games to make them bet-able, especially when Bills vs. Saints is the biggest model edge of Thursday’s Thanksgiving NFL slate.

Bills at Saints Betting Model Prediction