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NFL Odds: 74%, 61% Model Picks for Chargers vs Giants, Jaguars vs 49ers

NFL Odds: 74%, 61% Model Picks for Chargers vs Giants, Jaguars vs 49ers article feature image
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Sep 14, 2025; Arlington, Texas, USA; New York Giants quarterback Jaxson Dart (6). Credit: Kevin Jairaj-Imagn Images

Bet Labs gives bettors a couple of ways to pick two of Sunday's Week 4 spreads.

A premium system posting a 74% accuracy rate popped for Chargers vs. Giants in the early window for quarterback Jaxson Dart's debut.

Meanwhile, the Jaguars vs. 49ers tilt in the afternoon slot reveals a big-time edge casual bettors may overlook.

Let's check out a data-driven spread pick in the early window for Chargers vs. Giants, and another way to bet Jags-Niners later Sunday, Week 4.


NFL Spread Picks: Chargers vs. Giants, Jaguars vs. 49ers

Both the Chargers vs. Giants and Jaguars vs. 49ers games involve unique travel: A west coast team traveling east, and vice versa.

At 1 p.m. ET, the Chargers are favored by 6.5 against Dart and the Giants.

And our models suggest betting head coach