San Francisco 49ers Odds
49ers vs Chargers Odds
More Odds| Spread | Total | Moneyline | |
|---|---|---|---|
 LAC | -2.5-110 | o35.5-108 | -135 |
| SF | +2.5-115 | u35.5-111 | +114 |
49ers Injuries
All NFL Injuries- Trevis GipsonLB
Gipson is out with ankle
Out
49ers 2025 Schedule & Betting Odds
Depth Chart
| Starter | 2ND | 3RD | 4TH | ||
|---|---|---|---|---|---|
| QB | Brock Purdy | Mac Jones | Kurtis Rourke | Carter Bradley | |
| RB | Christian McCaffrey | Isaac Guerendo | Jordan James | Ke'Shawn Vaughn | Jeff Wilson |
| WR | Jauan Jennings | Jacob Cowing | Junior Bergen | ||
| TE | George Kittle | Luke Farrell | Brayden Willis | Jake Tonges | |
| LT | Trent Williams | Spencer Burford | Isaac Alarcon | ||
| LG | Ben Bartch | Nick Zakelj | |||
| C | Jake Brendel | Matt Hennessy | Drake Nugent | ||
| RG | Dominick Puni | Connor Colby | Drew Moss | ||
| RT | Colton McKivitz | Austen Pleasants | Isaiah Prince | ||
| LDE | Nick Bosa | Robert Beal | Jonathan Garvin | William Bradley-King | |
| RDE | Mykel Williams | Bryce Huff | Sam Okuayinonu | Trevis Gipson | Jaylon Allen |
| WLB | Dee Winters | Nick Martin | Curtis Robinson | Stone Blanton | Jalen Graham |
| MLB | Fred Warner | Luke Gifford | Tatum Bethune | Chazz Surratt | |
| LCB | Renardo Green | Dallis Flowers | Jakob Robinson | ||
| SS | Ji'Ayir Brown | Richie Grant | Jaylen Mahoney | ||
| FS | Jason Pinnock | Marques Sigle | Siran Neal | Derrick Canteen | |
| RCB | Deommodore Lenoir | Darrell Luter | Fabian Moreau | ||
| P | Thomas Morstead | ||||
| H | Fabian Moreau | ||||
| PR | Jacob Cowing | Junior Bergen | Jordan Watkins | Ricky Pearsall | |
| KR | Isaac Guerendo | Junior Bergen | Dallis Flowers | ||
| LS | Jon Weeks | ||||
| RWR | Ricky Pearsall | Jordan Watkins | Terique Owens | Robbie Chosen | |
| K | Jake Moody | ||||
| DT | Mykel Williams | Alfred Collins | Sebastian Valdez | Evan Anderson | |
| LWR | Russell Gage | Isaiah Hodgins | Malik Turner | ||
| NT | Jordan Elliott | C.J. West | Kalia Davis | Bruce Hector | |
| NB | Upton Stout | Chase Lucas | |||
| FB | Kyle Juszczyk |
San Francisco 49ers Odds, Bet Types, and Team History
The 49ers were a disappointing team last season, finishing the season with a 6-11 record, despite reaching the Super Bowl in 2023. They missed the playoffs, and it is clear that there have to be some tweaks made. However, the talent that remains on the roster still gives the fans a lot to hope for, and they may end up surprising many under quarterback Brock Purdy. Running back Christian McCaffrey remains on the roster as well, but it remains to be seen if the running back continues to perform well this year.
Will San Francisco finally break through and get the job done under Kyle Shanahan? Or will they continue to just miss that elusive Super Bowl championship?
Betting on the San Francisco 49ers
Sports betting in California still isn't legal after two props failed to pass. But, if you wish to place bets on the 49ers from one of the states where sports betting is legal, sign up with any online sportsbook.
When you sign up with an online sportsbook, there are a few options available for you to bet on the San Francisco 49ers:
San Francisco 49ers Spread
Betting point spreads are wagers based on the notion of a team winning or losing by a certain number of points. Here's an example of how the spread with a hypothetical 49ers game against the Seattle Seahawks as an example.
- 49ers -6.5 (-115)
- Seahawks -6.5 (-105)
In this situation, the 49ers are 6.5-point underdogs against the Cardinals. If the 49ers win the game by seven or more points, a $115 bet on the 49ers nets $100. If the Seahawks win the game outright or lose by seven points or less, a $105 bet banks $100.
San Francisco 49ers Moneyline
Betting against the 49ers moneyline was the move in 2024, as the team finished with 6-11 record. Moneyline bets are simple. All you have to do is pick who wins a given game. Your payout is based on the odds provided by the sportsbook. Check out this example of a 49ers moneyline bet.
- 49ers -300
- Seahawks +200
The minus (-) and plus (+) signs show who is the favorite and the underdog. The 49ers are the favorite in this example bet. It is easier to understand odds when you look at them with $100 increments in mind. A bet on the 49ers' odds means $300 bet earns $100 if it wins. With underdogs, it's the opposite. The Seahawks are +200 in this example, so a $100 bet delivers $200 in profit if successful.
Moneylines are frequently used when making parlays, which are multiple betting markets fused into one big bet. Let’s say you bet the 49ers moneyline and the Patriots moneyline in a given week. Both teams would need to win the game for your parlay to win. The risk is higher, but the payout is bigger due to increased odds. Use our Odds Calculator to calculate any bet amount or conversion.
San Francisco 49ers Over/Under
The over/under or point total is a bet on whether the score in a game goes over or under a certain line. Sportsbook give you a certain number, and you have to choose whether the game total will be over or under that number.
For example, suppose the 49ers play the Seahawks, and the over/under is set at 47 points. If you bet the over, that would necessitate the 49ers and the Seahawks to tally 47 or more total points for the bet to be successful. If you bet the under, that means you believe the two teams score under 47 total points. The bet can also push, which would happen if the game ends with exactly 47 points scored.
San Francisco 49ers Prop Bets
Player props are bets on a single player, which focuses on their performance in a statistical category in a given game or across the whole season. These are among the most fun options to wager on, since plenty of fans follow players and their brands. Here is an example of 49ers player prop below
- Over/Under: Brock Purdy passing yards: 3,825.5
In this example, you bet on whether Purdy ends the 2025-26 NFL regular season with over or under 3,825.5 yards.
San Francisco 49ers Futures
A futures bet is a wager that's based on an outcome that happens later in the season. Future bets can be made on how both team and individual players will do throughout a season. Some examples of popular futures bets include:
- San Francisco 49ers odds to win the NFC West
- San Francisco 49ers odds to win the NFC
- San Francisco 49ers odds to win the Super Bow
It is fair to say that NFL futures are generally elite plus-value odds. That means that if you win a futures wager, you can get a huge payout.
PrizePicks Promo Code
PrizePicks is a Daily Fantasy Sports provider that began operating in late 2018. The game can be explained in one simple statement; choose whther your favorite players get "More" or "Less" in statistical categories to win cash. Californians can play PrizePicks until online sports betting becomes legalized by downloading the app.