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Cardinals vs. 49ers Odds & Betting Predictions - September 27, 2026

Cardinals at 49ers

8:05 pm • FOX

Arizona Cardinals

0-0
@

San Francisco 49ers

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Cardinals at 49ers Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Cardinals
0-0
N/A
N/A
N/A
49ers
0-0
N/A
N/A
N/A
location pinSunday 8:05 p.m.
September 27, 2026
Levi's StadiumSanta Clara

Cardinals vs. 49ers Props

Prop Projections

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Prop Odds Comparison

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Line Movement Tracker

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Cardinals vs. 49ers Public Betting Percentages

Away Logo

Cardinals

Public

Home Logo

49ers

50%

Bets%

50%

Money%

NFL Public Betting Right Arrow

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
49ers		N/AN/AN/AN/AN/A
Cardinals		N/AN/AN/AN/AN/A

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
49ers		N/AN/AN/AN/AN/A
Cardinals		N/AN/AN/AN/AN/A

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
49ers		N/AN/AN/AN/AN/A
Cardinals		N/AN/AN/AN/AN/A

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Aug 28th@LVW 18-12+3.5 WU 37.5SF +139
Aug 21st@LACW 41-17+2.5 WO 44.5SF +132
Aug 14thTENL 13-19+6.5 WU 40TEN +237
Jan 18th@SEAL 6-41+7 LO 44.5SEA +250
Jan 11th@PHIW 23-19+5.5 WU 44.5SF +205
Depth Charts
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Starter2ND3RD4TH
QBBrock PurdyMac JonesKurtis Rourke
RBChristian McCaffreyJordan JamesKaelon BlackSincere McCormick
WRDe'Zhaun StriblingChristian KirkWill Pauling
TEJake TongesLuke FarrellBrayden Willis
LTTrent WilliamsEnrique CruzVederian Lowe
LGCarver WillisBrett Toth
CJake BrendelDrake Nugent
RGDominick PuniConnor ColbyNick Zakelj
RTColton McKivitzAusten PleasantsIsaac Alarcon
LDEKeion White
RDENick BosaSam OkuayinonuRomello HeightOgbo Okoronkwo
WLBDre GreenlawLuke GiffordNick MartinGarret Wallow
MLBFred WarnerTatum BethuneJaden DuggerJalen Graham
LCBRenardo GreenJack JonesJakob Robinson
SSMalik MustaphaMarques SigleAshtyn Davis
FSJi'Ayir BrownSiran NealJalen Stroman
RCBDeommodore LenoirEphesians Prysock
PCorliss Waitman
HCorliss Waitman
PRJacob CowingJordan Watkins
KRDeebo SamuelJacob Cowing
LSJon Weeks
LWRMike EvansDemarcus RobinsonKhaDarel Hodge
KEddy Pineiro
NTAlfred CollinsGracen HaltonSebastian ValdezJames Thompson
FBKyle Juszczyk
DTOsa OdighizuwaC.J. West
RWRDeebo SamuelJordan WatkinsJacob CowingWesley Grimes
NBUpton StoutNate Hobbs

Cardinals vs. 49ers Odds Comparison

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Cardinals at 49ers Team Totals

MatchupOverUnder
Cardinals
0-0
N/A
N/A
49ers
0-0
N/A
N/A