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Cardinals vs. 49ers Odds & Betting Predictions - September 27, 2026

Cardinals at 49ers

8:05 pm • FOX

Arizona Cardinals

2-4
30
30 - 36

San Francisco 49ers

6-0
36

Cardinals at 49ers Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Cardinals
2-4
+11.5
+7.5-111
o48.5-110
+310
49ers
6-0
u46.5
-7.5-110
u48.5-110
-400
location pinSunday 8:05 p.m.
September 27, 2026
Levi's StadiumSanta Clara
Cardinals vs. 49ers Expert Picks
Stuck 🚨
Stuck 🚨
Last 30d: 61-67-2 (-0.5u)
ARI +8.5-110
0.27u
Are there even any DL left?
Matt Moore
Matt Moore
Last 30d: 37-41-8 (-0.9u)
SF -8.5-108
0.55u
Tyler Shoemaker
Tyler Shoemaker
Last 30d: 33-39-0 (-1.7u)
Under 48-110
1.1u
Under 49.5 (Live)-112
1.12u
Sean Koerner🔮
Sean Koerner🔮
Last 30d: 49-61-0 (+1.8u)
B.Purdy o235.5 Pass Yds-113
0.5u
Talked about this on Action Live
Anthony Dabbundo
Anthony Dabbundo
Last 30d: 43-59-0 (-18.2u)
ARI o19.5-110
1u
Doug Ziefel
Doug Ziefel
Last 30d: 370-388-7 (+21.5u)
T.McBride Anytime TD Scorer Yes+180
0.28u
C.McCaffrey o13.5 Rush Att-114
0.5u
Grant Neiffer
Grant Neiffer
Last 30d: 24-79-4 (+1.7u)
T.McBride Anytime TD Scorer Yes+200
0.25u
OldSchool0909
Last 30d: 40-47-1 (-3.0u)
ARI +8.5-110
0.91u
Doug Kezirian
Doug Kezirian
Last 30d: 7-8-1 (-2.4u)
SF -8.5-109
1.09u
MJC
MJC
Last 30d: 8-6-0 (+7.3u)
G.Kittle Anytime TD Scorer Yes+180
1.35u
Brandon Anderson
Brandon Anderson
Last 30d: 28-96-0 (-14.2u)
SF -12.5+160
0.25u
Brandon’s playground Week 3 bets
SF -18.5+300
0.25u
Brandon’s playground Week 3 bets
SF -23.5+600
0.25u
Brandon’s playground Week 3 bets
The Degenerates
The Degenerates
Last 30d: 47-51-2 (-7.6u)
ARI u19.5-108
1.08u
Kyle Murray
Kyle Murray
Last 30d: 152-130-9 (+26.8u)
J.Love o14.5 Rec Yds-113
1u
Frank Ammirante
Frank Ammirante
Last 30d: 99-89-0 (-2.9u)
J.Love o38.5 Rush Yds-110
1u
ARI +8.5-112
1u
Gilles Gallant
Gilles Gallant
Last 30d: 22-63-1 (-5.3u)
T.McBride Anytime TD Scorer Yes+200
0.5u
Obligatory McBride TD Bet if its +200 or better. IYKYK.
Topper
Topper
Last 30d: 175-150-8 (+18.1u)
ARI +7.5-105
0.95u
Dog off Big Loss Overall: 255-180-4,59% (ROI:13%) Season:1-0-0,100% (ROI:87%) Early szn Bounce Back Overall: 336-232-10,59% (ROI:15%) Season:4-4-0,50% (ROI:-4%) #TSA
Under 48.5-108
1u
Open Air Unders: Divisional Drift - copy Overall: 306-221-6,58% (ROI:13%) Season:2-0-0,100% (ROI:92%) Open Air Unders: Divisional Drift Overall: 426-320-11,57% (ROI:11%) Season:2-2-0,50% (ROI:-4%) #TSA
Action Pod NFL Picks
Action Pod NFL Picks
Last 30d: 37-98-0 (-11.0u)
SF -12.5+160
0.63u
@wheatonbrando https://podcasts.apple.com/us/podcast/nfl-betting-playground-week-3/id1004530793?i=1000791577819
SF -23.5+600
0.17u
@wheatonbrando https://podcasts.apple.com/us/podcast/nfl-betting-playground-week-3/id1004530793?i=1000791577819
SF -18.5+300
0.33u
@wheatonbrando https://podcasts.apple.com/us/podcast/nfl-betting-playground-week-3/id1004530793?i=1000791577819
SF -8.5-108
1u
@Stuckey2 https://podcasts.apple.com/us/podcast/nfl-week-3-betting-preview/id1004530793?i=1000791367319
Mjaybrod
Mjaybrod
Last 30d: 50-78-1 (-29.3u)
ARI o19.5-120
1.67u
NFL POD
Adam Kaufman
Adam Kaufman
Last 30d: 317-302-11 (-21.8u)
SF -8-115
0.57u
💰🦡 Jake
💰🦡 Jake
Last 30d: 86-98-1 (+18.6u)
Under 48.5-110
1.1u
Charlie DiSturco
Charlie DiSturco
Last 30d: 105-194-1 (+12.0u)
Over 47.5-113
1u
Derek Carty
Derek Carty
Last 30d: 22-21-0 (+4.5u)
C.McCaffrey o13.5 Rush Att-101
1u
THE BLITZ is forecasting 17.48 rush attempts for Christian McCaffrey. The oddsmakers' implied projection is 14.26 rush attempts, so I believe there is some value here. If you take the over, you’d be projected to win 67% of the time resulting in a 33% ROI with expected value of $33.12 (based on a $100 wager). This play is good down to at least -137. Love THE BLITZ? Get all of Carty’s sports betting projections at EV Analytics: https://evanalytics.com/products/nfl-premium-subscription?ref=zdlkmgz
TAN Pod Touchdown Show
TAN Pod Touchdown Show
Last 30d: 20-96-6 (-8.9u)
L.Farrell Anytime TD Scorer Yes+1000
0.1u
@The_Oddsmaker https://podcasts.apple.com/us/podcast/nfl-touchdown-show-week-3/id1004530793?i=1000791547972
T.McBride Anytime TD Scorer Yes+205
0.49u
@The_Oddsmaker https://podcasts.apple.com/us/podcast/nfl-touchdown-show-week-3/id1004530793?i=1000791547972

Cardinals vs. 49ers Previews & Analysis

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    Cardinals vs. 49ers: Can Brock Purdy Be Stopped?

    Doug Kezirian•
    Sep 27, 2026 UTC
  • Anderson's Week 3 Mega-Preview: Props, Parlays, More! article feature image

    Anderson's Week 3 Mega-Preview: Props, Parlays, More!

    Brandon Anderson•
    Sep 27, 2026 UTC
  • Stuckey's NFL Week 3 Picks Against the Spread article feature image

    Stuckey's NFL Week 3 Picks Against the Spread

    Stuckey•
    Sep 27, 2026 UTC
  • Week 3 Luck Rankings Dashboard: All Edges in One Place article feature image

    Week 3 Luck Rankings Dashboard: All Edges in One Place

    Nick Giffen•
    Sep 27, 2026 UTC
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Cardinals vs. 49ers Props

Prop Projections

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Cardinals vs. 49ers Public Betting Percentages

Away Logo

Cardinals

Public

Home Logo

49ers

16%

Bets%

84%

Money%

NFL Public Betting Right Arrow

Betting Trends

  • 49ers are 5-0 in their last 5 games.
  • 49ers are 3-2 in their last 5 games against the spread
  • 49ers are 1-0 in their road games against the spread
  • The totals have gone OVER in 2 of 49ers' last 5 games
  • The totals have gone OVER in 2 of 49ers' 4 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
49ers		4-22-21-02-22-0
Cardinals		3-30-23-10-13-2

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
49ers		3-32-21-02-21-1
Cardinals		3-31-12-21-02-3

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
49ers		6-0N/AN/A4-02-0
Cardinals		2-4N/AN/A0-12-3

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Sep 20thMIAW 35-13-13 WO 45SF -1000
Sep 11th@LAW 27-7+3.5 WU 47.5SF +166
Aug 28th@LVW 18-12+3.5 WU 37.5SF +139
Aug 21st@LACW 41-17+2.5 WO 44.5SF +132
Aug 14thTENL 13-19+6.5 WU 40TEN +237

Cardinals vs. 49ers Injury Updates

Cardinals Injuries

  • James Conner
    RB

    Conner is out with foot

    Out

  • Hunter Long
    TE

    Long is out with knee

    Out

  • Jeremiyah Love
    RB

    Love is doubtful with ankle

    Doubtful

49ers Injuries

  • Mike Evans
    WR

    Evans is out with achilles

    Out

  • Demarcus Robinson
    WR

    Robinson is out with ankle

    Out

  • Christian Kirk
    WR

    Kirk is questionable with calf

    Questionable

  • Deebo Samuel
    WR

    Samuel is out with hamstring

    Out

  • Jake Tonges
    TE

    Tonges is out with knee

    Out

  • De'Zhaun Stribling
    WR

    Stribling is out with ankle

    Out

See more NFL Injuries Right Arrow
Team Stats

Total

365
Total Yards
437
81
Total Plays
50
4.5
Yards Per Play
8.7

Passing

280
YDS
297
38/52
Comps/Atts
15/27
5.037
YPA
11
2/0
TDs/INTs
4/0
2/8
Sacks/Yards
0/0

Rushing

93
Rush Yards
140
27
Attempts
23
3.444
YPC
6.087
1
TDs
1

Turnovers

0
Fumbles Lost
1
0
Interceptions
0

Efficiency

3/5 60%
Redzone
2/2 100%
9/18 0%
3rd Down
5/8 0%
2/2 0%
4th Down
0/0 0%

First Downs

27
Total
23
18
Pass
14
6
Rush
7
3
Penalty
2

Misc

10/86
Penalties/Yards
7/69
38:44
Possession
21:16

Cardinals vs. 49ers Odds Comparison

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Cardinals at 49ers Team Totals

MatchupOverUnder
Cardinals
2-4
N/A
N/A
49ers
6-0
N/A
N/A