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49ers vs. Rams Odds & Betting Predictions - September 11, 2026

49ers at Rams

12:35 am • Netflix

San Francisco 49ers

1-1
@

Los Angeles Rams

2-1

49ers at Rams Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
49ers
1-1
+2.5
+2.5-115
o49.5-110
+115
Rams
2-1
u49.5
-2.5-105
u49.5-110
-140
location pinFriday 12:35 a.m.
September 11, 2026

49ers vs. Rams Props

Prop Projections

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Prop Odds Comparison

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49ers vs. Rams Public Betting Percentages

Away Logo

49ers

Public

Home Logo

Rams

100%

Bets%

0%

Money%

NFL Public Betting Right Arrow

Betting Trends

  • Rams are 4-1 in their last 5 games.
  • Rams are 4-1 in their last 5 games against the spread
  • Rams are 5-3 in their road games against the spread
  • The totals have gone OVER in 1 of Rams' last 5 games
  • The totals have gone OVER in 3 of Rams' 8 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Rams		12-56-25-311-41-1
49ers		10-73-57-28-32-4

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Rams		10-73-57-18-72-0
49ers		10-74-46-37-43-3

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Rams		12-5N/AN/A12-30-2
49ers		12-5N/AN/A10-12-4

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Jan 25th@SEAL 27-31+2.5 LO 45.5SEA +120
Jan 18th@CHIW 20-17-3.5 LU 49.5LA -205
Jan 10th@CARW 34-31-10 LO 45LA -567
Jan 4thARIW 37-20-14.5 WO 49.5LA -1248
Dec 30th@ATLL 24-27-7.5 LO 49ATL -382

49ers vs. Rams Injury Updates

49ers Injuries

  • George Kittle
    TE

    Kittle is out with achilles

    Out

  • Brandon Aiyuk
    WR

    Aiyuk is out with knee

    Out

  • Colton Dowell
    WR

    Dowell is out with knee

    Out

  • Jacob Cowing
    WR

    Cowing is out with hamstring

    Out

Rams Injuries

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    Player Stats
    • passing yards
      Matthew Stafford logo
      Matthew Stafford
      4707
      pyds
    • passing touchdowns
      Matthew Stafford logo
      Matthew Stafford
      46
      ptd
    • rushing yards
      Kyren Williams logo
      Kyren Williams
      1252
      ryds
    • rushing touchdowns
      Kyren Williams logo
      Kyren Williams
      10
      rtd
    Depth Charts
    Right Arrow
    Starter2ND3RD4TH
    QBMatthew StaffordJimmy GaroppoloStetson Bennett
    RBKyren WilliamsBlake CorumJarquez HunterRonnie RiversJordan Waters
    WRTutu AtwellXavier Smith
    TETyler HigbeeColby ParkinsonTerrance FergusonDavis AllenMark Redman
    LTAlaric JacksonD.J. HumphriesAJ Arcuri
    LGSteve AvilaWyatt Bowles
    CColeman SheltonBeaux LimmerDylan McMahon
    RGKevin DotsonJustin Dedich
    RTWarren McClendonDavid Quessenberry
    RDEBraden FiskeDesjuan Johnson
    LCBDarious WilliamsEmmanuel ForbesCam Lampkin
    SSKam CurlJaylen McCollough
    FSKamren KinchensTanner IngleNate Valcarcel
    RCBAhkello WitherspoonCobie DurantDerion Kendrick
    PEthan Evans
    HEthan Evans
    PRXavier Smith
    KRJordan WhittingtonBlake Corum
    LOLBByron Young
    LWRDavante AdamsJordan WhittingtonTru Edwards
    RWRPuka NacuaKonata MumpfieldBrennan Presley
    RILBOmar SpeightsElias Neal
    DTKobie TurnerTyler Davis
    LILBNate LandmanTroy ReederShaun Dolac
    NTPoona FordTy HamiltonBill Norton
    NBQuentin LakeJosh Wallace
    ROLBJared VerseJosaiah StewartNick Hampton

    49ers vs. Rams Odds Comparison

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    49ers at Rams Team Totals

    MatchupOverUnder
    49ers
    1-1
    N/A
    N/A
    Rams
    2-1
    N/A
    N/A