Broncos vs. 49ers Odds & Betting Predictions - October 4, 2026

Broncos at 49ers

8:25 pm • CBS
14 - 24

Broncos at 49ers Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Broncos
2-2
+2.5
+3-110
o48.5-105
+140
49ers
4-0
u46.5
-3-109
u48.5-112
-166
location pinSunday 8:25 p.m.
October 04, 2026
Levi's StadiumSanta Clara
Broncos vs. 49ers Expert Picks
Sir Lockselot
Sir Lockselot
Last 30d: 7-32-0 (-14.8u)
DEN +145 (Live)
$120.00
John Feltman
John Feltman
Last 30d: 90-74-0 (+3.3u)
Over 48.5-105
0.53u
Nick Giffen
Nick Giffen
Last 30d: 39-67-0 (+1.8u)
B.Purdy u17.5 Rush Yds-113
1.02u
Not sure how i made it only 0.1u earlier lol. Meant to do win 1u. Topping off
Gilles Gallant
Gilles Gallant
Last 30d: 24-45-1 (+9.2u)
C.Sutton Anytime TD Scorer Yes+250
0.5u
Scott Rickenbach
Scott Rickenbach
Last 30d: 84-89-2 (-16.5u)
DEN +3-102
1u
Nick Giffen
Nick Giffen
Last 30d: 39-67-0 (+1.8u)
B.Purdy u17.5 Rush Yds-112
0.11u
Take 18.5 at 365 but will track at 17.5 since thats more widely available
Derek Carty
Derek Carty
Last 30d: 34-59-5 (-11.9u)
M.Evans u3.5 Recs+114
1u
There may be some value on the receptions prop for Mike Evans. THE BLITZ is projecting him to record 2.87 receptions, and the oddsmakers are implying 4.06. The model believes there is a 68% chance he records fewer than 3.5 receptions. If you can get the under at +114 or better, there is some great value here. This play is good down to at least -146. Love THE BLITZ? Get all of Carty’s sports betting projections at EV Analytics: https://evanalytics.com/products/nfl-premium-subscription?ref=zdlkmgz
Sandy Plashkes
Sandy Plashkes
Last 30d: 98-77-3 (+48.6u)
SF u24.5-105
1u
@Mjaybrxd
Mjaybrod
Mjaybrod
Last 30d: 62-77-1 (-12.3u)
SF u24.5-110
1.82u
NFL POD
Doug Ziefel
Doug Ziefel
Last 30d: 357-387-8 (+14.9u)
C.McCaffrey o39.5 Rec Yds-113
0.56u
K.Black u23.5 Rush Yds-114
0.5u
B.Nix u1.5 Pass TDs-122
0.5u
Brandon Anderson
Brandon Anderson
Last 30d: 38-81-0 (+5.6u)
K.Black o22.5 Rush Yds-113
0.75u
Brandon’s playground pod Week 4
K.Black 40+ Rushing Yards Yes+306
0.15u
Brandon’s playground pod Week 4
K.Black 50+ Rushing Yards Yes+560
0.15u
Brandon’s playground pod Week 4
K.Black 60+ Rushing Yards Yes+960
0.1u
Brandon’s playground pod Week 4
Frank Ammirante
Frank Ammirante
Last 30d: 129-129-2 (-10.5u)
SF -2.5-120
1u
C.McCaffrey o66.5 Rush Yds-109
1.09u
Kyle Murray
Kyle Murray
Last 30d: 146-130-7 (+15.1u)
R.Harvey o3.5 Recs+102
1.02u
Matt Moore
Matt Moore
Last 30d: 29-45-1 (-5.2u)
DEN +2.5+100
1.1u
Action Pod NFL Picks
Action Pod NFL Picks
Last 30d: 53-88-0 (+6.6u)
K.Black o22.5 Rush Yds-115
1u
K.Black 40+ Rushing Yards Yes+306
0.33u
K.Black 50+ Rushing Yards Yes+560
0.18u
K.Black 60+ Rushing Yards Yes+960
0.1u
TAN Pod Touchdown Show
TAN Pod Touchdown Show
Last 30d: 27-91-3 (-2.5u)
C.Sutton Anytime TD Scorer Yes+240
0.42u
L.Farrell Anytime TD Scorer Yes+1000
0.1u
Kody Malstrom
Kody Malstrom
Last 30d: 68-54-2 (+3.8u)
Under 48.5-108
0.5u
SF -2.5-108
0.5u
Action Pod NFL Picks
Action Pod NFL Picks
Last 30d: 53-88-0 (+6.6u)
Kendra Middleton
Kendra Middleton
Last 30d: 14-22-0 (-2.3u)
DEN +2.5+106
0.5u
Kev Mahserejian
Kev Mahserejian
Last 30d: 11-17-0 (-6.3u)
DEN +2.5-103
1u
Nick Griffith
Last 30d: 43-31-0 (+11.9u)
DEN +3-117
1.17u
RoyalsProps
RoyalsProps
Last 30d: 38-35-1 (-3.5u)
J.Waddle o56.5 Rec Yds-114
1.14u
OldSchool0909
Last 30d: 91-144-2 (-54.7u)
DEN +2.5+100
1u
DEN +130
1u
Adam Kaufman
Adam Kaufman
Last 30d: 198-211-5 (-24.3u)
SF -2.5-120
1u
Under 23.5 (1H)-120
0.21u
SF o23.5-128
0.2u
SF -132 (2Q)
0.19u
SF -136 (1H)
0.25u
DEN u10.5 (1H)-140
0.18u
Under 13.5 (2Q)-104
0.24u
SF -122 (1Q)
0.5u
Brandon Kravitz
Brandon Kravitz
Last 30d: 50-60-1 (-2.6u)
SF -3+106
2.12u
OldSchool0909
Last 30d: 91-144-2 (-54.7u)
DEN +2.5-104
1u

Broncos vs. 49ers Previews & Analysis

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    Broncos vs. 49ers: Think Twice Before Fading Bo Nix

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  • NFL Anytime Touchdown Machine: Live TD Odds & Trends article feature image

    NFL Anytime Touchdown Machine: Live TD Odds & Trends

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  • Week 4 Luck Rankings Dashboard: All Edges in One Place article feature image

    Week 4 Luck Rankings Dashboard: All Edges in One Place

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Broncos vs. 49ers Props

Prop Projections

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Broncos vs. 49ers Public Betting Percentages

Away Logo

Broncos

Public

43%

Bets%

57%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
49ers
3-12-1N/A2-11-0
Broncos
2-22-00-22-00-2

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
49ers
2-22-1N/A2-10-1
Broncos
1-31-10-21-10-2

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
49ers
4-0N/AN/A3-01-0
Broncos
2-2N/AN/A2-00-2

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Sep 27thARIW 36-30-7.5 LO 48.5SF -400
Sep 20thMIAW 35-13-13 WO 45SF -1000
Sep 11th@LAW 27-7+3.5 WU 47.5SF +166
Aug 28th@LVW 18-12+3.5 WU 37.5SF +139
Aug 21st@LACW 41-17+2.5 WO 44.5SF +132

Broncos vs. 49ers Injury Updates

Broncos Injuries

  • Jonah Coleman
    RB

    Coleman is out with ankle

    Out

49ers Injuries

  • Mike Evans
    WR

    Evans is questionable with ribs

    Questionable

  • Demarcus Robinson
    WR

    Robinson is out with ankle

    Out

  • Christian Kirk
    WR

    Kirk is out with calf

    Out

  • Jake Tonges
    TE

    Tonges is out with knee

    Out

  • De'Zhaun Stribling
    WR

    Stribling is out with ankle

    Out

Team Stats
296
Total Yards
358
64
Total Plays
65
4.6
Yards Per Play
5.5
214
YDS
218
25/42
Comps/Atts
19/30
5.095
YPA
7.267
1/0
TDs/INTs
2/0
0/0
Sacks/Yards
0/0
82
Rush Yards
140
22
Attempts
35
3.727
YPC
4
0
TDs
1

Turnovers

1
Fumbles Lost
0
0
Interceptions
0

Efficiency

1/1 100%
Redzone
2/3 66.67%
8/17 0%
3rd Down
6/13 0%
1/1 0%
4th Down
1/2 0%

First Downs

16
Total
20
10
Pass
8
6
Rush
11
0
Penalty
1
7/44
Penalties/Yards
1/5
30:53
Possession
29:07

Broncos vs. 49ers Odds Comparison

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Broncos at 49ers Team Totals

MatchupOverUnder
Broncos
2-2
N/A
N/A
49ers
4-0
N/A
N/A