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Panthers vs Lions Odds, Picks, Parlay for Sunday Night Football

Panthers vs Lions Odds, Picks, Parlay for Sunday Night Football article feature image
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Detroit Lions running back Jahmyr Gibbs (0) next to wide receiver Isaac TeSlaa (18) celebrate a touchdown against New York Jets during the second half at Ford Field in Detroit on Sunday, Sept. 27, 2026.

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The NFL Sunday Week 4 slate concludes with an NFC Sunday Night Football tilt between the Carolina Panthers and Detroit Lions at Bank of America Stadium in Charlotte, North Carolina. Panthers vs. Lions will broadcast live tonight on NBC and Peacock at 8:20 p.m. ET.

Continue below for my Panthers vs Lions parlay, which includes picks and props for Darren Waller and Jahmyr Gibbs.


Panthers vs Lions Parlay

  • Darren Waller Over 3.5 Receptions (+100)
  • Brycen Tremayne Over 2.5 Receptions (-119)
  • Jahmyr Gibbs 2+ TD (+142) 

Parlay Odds: +791

Odds via DraftKings are subject to change*


Panthers vs Lions Odds

Lions Logo
Sunday, Oct 4
8:20 p.m. ET
NBC/Peacock
Panthers Logo
Lions Odds
SpreadTotalMoneyline
-3.5
-120
51.5
-112o / -108u
-198
Panthers Odds
SpreadTotalMoneyline
+3.5
+100
51.5
-112o / -108u
+164
Odds via DraftKings. Get up-to-the-minute NFL odds here.
DraftKings Logo


Panthers vs Lions Preview

The Lions head to Carolina to face a decimated Panthers roster.

Week 3 was not kind to the Panthers' rest-of-season outlook. Starting cornerbacks Jaycee Horn and Mike Jackson were both placed on injured reserve, while offensive cornerstones Jalen Coker and Damien Lewis suffered injuries.

Meanwhile, the Lions are mostly healthy, but struggling to defend. They have allowed 31.7 points per game through the first month of the season.

The only reinforcement is the impending return of star safety Brian Branch. Unfortunately, Branch is returning from a torn achilles tendon and may not be himself this season (or ever again).

This matchup has a total of 51.5, despite potential weather conditions, for a reason.

Carolina's defense ranks 18th in DVOA (via FTN), while the Detroit's defense ranks 28th. The Panthers defense may be worse than the Lions' going forward, with Carolina's secondary now starting backups at multiple CB slots.

This will likely be a game where the Lions lead early (-3.5 favorites on the road) and force Carolina to throw throughout the second half. Carolina's offense has started much better than expected, but without Coker or Lewis, explosive plays may be limited.

The Panthers can still score, but they must rely on their secondary pass-catchers.

Former first-round pick Xavier Legette is out, allowing for explosive depth WR Brycen Tremayne to fill in and play a season-high number of snaps. His 1.80 yards per route run this season and 9.6 career yards per target make him a solid target for Bryce Young.

Furthermore, offseason addition Darren Waller will be needed more than usual. He has a 19.4% target share per route this season and has proven himself valuable with two touchdowns in three games. Take the over on Waller (3.5 REC +100) and Tremayne (2.5 REC -119).

Also, Jahmyr Gibbs is on a ridiculous pace. He is second in rushes inside the 20 and inside the 5, leads the NFL with six total TDs, and is facing the league's 23rd-ranked rushing defense.

This game is a perfect spot for Gibbs to find the end zone multiple times for the third time in four games. Take him at +142 to score twice and add it to today's parlay.

Panthers vs Lions Same-Game Parlay

  • Darren Waller Over 3.5 Receptions (+100) 
  • Brycen Tremayne Over 2.5 Receptions (-119)
  • Jahmyr Gibbs 2+ TD (+142) 

Parlay Odds: +791

Author Profile
About the Author
Kevork Mahserejian • Verified Action Expert

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