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Astros vs. Orioles Odds & Betting Predictions - August 21, 2025

Astros at Orioles

11:15 pm • FOX
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Houston Astros

69-56
@

Baltimore Orioles

58-67
Starting Pitchers
pitcherteameraw-l
Brandon Young logoB.YoungBaltimore Orioles logo0.000-0
Jason Alexander logoJ.AlexanderHouston Astros logo0.000-0

Astros at Orioles Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Astros
69-56
N/A
N/A
N/A
Orioles
58-67
N/A
N/A
N/A
location pinThursday 11:15 p.m.
August 21, 2025
Oriole Park at Camden YardsBaltimore
thermometer image73°Fahrenheit
rain image6%Rain
wind image10Wind

Prop Odds Comparison

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No props found

Line Movement Tracker

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Astros vs. Orioles Public Betting Percentages

Away Logo

Astros

Public

Home Logo

Orioles

50%

Bets%

50%

Money%

MLB Public Betting Right Arrow

Betting Trends

  • Orioles are 4-1 in their last 5 games.
  • Orioles are 5-0 in their last 5 games against the spread
  • Orioles are 32-33 in their road games against the spread
  • The totals have gone OVER in 3 of Orioles' last 5 games
  • The totals have gone OVER in 30 of Orioles' 60 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Orioles		59-6627-3332-3320-3637-30
Astros		62-6330-3532-2834-5028-11

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Orioles		53-68-430-28-223-40-228-26-224-41-2
Astros		57-62-629-35-128-27-539-43-216-19-4

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Orioles		58-6730-3028-3725-3131-36
Astros		69-5638-2731-2946-3823-16

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Aug 18th@BOSW 6-3-1.5 WO 8BAL +105
Aug 17th@HOUW 12-0-1.5 WO 8.5BAL -101
Aug 16th@HOUL 4-5+1.5 WO 8.5HOU +118
Aug 16th@HOUW 7-0+1.5 WU 7.5BAL +184
Aug 14thSEAW 5-3+1.5 WU 9.5BAL +111

Astros vs. Orioles Injury Updates

Astros Injuries

  • Jake Meyers
    CF

    Meyers is out with calf

    Out

  • Luis Garcia
    SP

    Garcia is out with elbow

    Out

  • Pedro Leon
    RF

    Leon is out with knee

    Out

  • J.P. France
    SP

    France is out with shoulder

    Out

  • Hayden Wesneski
    RP

    Wesneski is out with elbow

    Out

Orioles Injuries

  • Albert Suarez
    RP

    Suarez is out with shoulder

    Out

  • Jorge Mateo
    SS

    Mateo is out with hamstring

    Out

  • Kyle Bradish
    SP

    Bradish is out with elbow

    Out

  • Grayson Rodriguez
    SP

    Rodriguez is out with elbow

    Out

  • Tyler Wells
    SP

    Wells is out with elbow

    Out

  • Adley Rutschman
    C

    Adley Rutschman has been scratched Tuesday.

    Out

See more MLB Injuries Right Arrow

Astros vs. Orioles Odds Comparison

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Astros at Orioles Team Totals

MatchupOverUnder
Astros
69-56
N/A
N/A
Orioles
58-67
N/A
N/A