Brewers vs. Cardinals Odds & Betting Predictions - September 21, 2025

Brewers at Cardinals

6:15 pm • FDSMW

Milwaukee Brewers

5-1

1 - 5

St. Louis Cardinals

4-3

pitcher		team	era	w-l
M.Liberatore			4.21	8-12
R.Gasser			3.18	0-2

MatchupOpenSpreadTotalMoneyline
Brewers 5-1	-1.5	-1.5+125	o8.5-110	-132
Cardinals 4-3	u9	+1.5-150	u8.5-110	+113

Sunday 6:15 p.m.

September 21, 2025

Busch StadiumSt. Louis

Under 8.5-105

0.5u

Could see this as a potential rest spot for some Milwaukee bats with their magic number down to 1 to clinch division. Cardinals already sitting Arenado/Donovan/Pozo and starting five LHB vs the lefty Gasser, so it sets up well for Gasser. Can wait for MIL lineup as they still need to win this game to clinch and Cardinals aren’t playing for anything, but like how this matches up for Gasser and think Liberatore could be in a good spot too if Brewers rest someone like Contreras (who has played five straight games)

No props found

MLB Public Betting

Cardinals are 2-3 in their last 5 games.
Cardinals are 2-3 in their last 5 games against the spread
Cardinals are 0-1 in their road games against the spread
The totals have gone OVER in 1 of Cardinals' last 5 games
The totals have gone OVER in 3 of Cardinals' 6 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Cardinals	4-3	4-2	0-1	N/A	4-3
Brewers	5-1	5-1	N/A	5-1	N/A

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Cardinals	3-4	3-3	0-1	N/A	3-4
Brewers	4-2	4-2	N/A	4-2	N/A

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Cardinals	4-3	4-2	0-1	N/A	4-3
Brewers	5-1	5-1	N/A	5-1	N/A

date	opponent	score	spread	over/under	moneyline
Sep 20th	MIL	L 2-3	+1.5 W	U 8.5	MIL +121
Sep 20th	MIL	W 7-1	+1.5 W	O 7.5	-
Sep 17th	CIN	L 2-6	+1.5 L	U 8.5	CIN +102
Sep 16th	CIN	W 3-0	+1.5 W	U 8	STL +105
Sep 15th	CIN	L 6-11	+1.5 L	O 8.5	CIN -113

Lars Nootbaar
LF
Nootbaar is out with heel
Out
Hunter Dobbins
SP
Dobbins is out with knee
Out

Akil Baddoo
LF
Baddoo is out with quad
Out
Andrew Vaughn
1B
Vaughn is out with hand
Out
Quinn Priester
SP
Priester is out with wrist
Out

See more MLB Injuries

PITCHER	PC	IP	K	ER
LR.Gasser, P	45	3	2	2
RE.Fedde, P	56	4	1	3
LR.Zastryzny, P	5	0.2	1	0
RG.Anderson, P	14	0.1	0	0

HITTERS	H-AB	R	RBI
1J.Chourio, RF	0-4	0	1
2I.Collins, LF	0-3	0	0
3A.Vaughn, 1B	0-4	0	0
4R.Hoskins, DH	0-3	0	0
4C.Yelich, PH	0-1	0	0
4C.Yelich, DH	0-1	0	0
5C.Durbin, 3B	0-2	0	0
6A.Monasterio, 2B	3-4	0	0
7D.Jansen, C	0-4	0	0
8B.Perkins, CF	2-3	0	0
8B.Turang, PH	0-1	0	0
9J.Ortiz, SS	2-3	1	0
9J.Bauers, PH	0-0	0	0

PITCHER	PC	IP	K	ER
LM.Liberatore, P	85	5	6	1
RM.Svanson, P	35	2	2	0
RR.Fernandez, P	16	1	2	0
RR.O'Brien, P	15	1	0	0

HITTERS	H-AB	R	HR	RBI
1T.Saggese, SS	0-4	0	0	0
2I.Herrera, DH	1-2	2	1	2
3A.Burleson, 1B	1-3	0	0	0
4L.Nootbaar, LF	0-3	0	0	0
4N.Church, LF	0-0	0	0	0
5J.Walker, RF	0-2	1	0	0
6N.Arenado, 3B	0-0	0	0	0
6N.Gorman, 3B	0-3	1	0	0
7J.Fermin, 2B	1-3	0	0	3
8J.Crooks, C	0-4	0	0	0
9V.Scott, CF	0-2	1	0	0