Guardians vs. Twins Odds & Betting Predictions - September 20, 2025

Guardians at Twins

12:10 am • CLEG

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Cleveland Guardians

@

Minnesota Twins

pitcher		team	era	w-l
P.Lopez			0.00	0-0
T.Bibee			0.00	0-0

MatchupOpenSpreadTotalMoneyline
Guardians 79-71	N/A	N/A	N/A
Twins 66-85	N/A	N/A	N/A

location pin

Saturday 12:10 a.m.

September 20, 2025

Target FieldMinneapolis

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70°Fahrenheit

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29%Rain

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6Wind

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MLB Public Betting

Twins are 2-3 in their last 5 games.
Twins are 2-3 in their last 5 games against the spread
Twins are 37-38 in their road games against the spread
The totals have gone OVER in 3 of Twins' last 5 games
The totals have gone OVER in 37 of Twins' 76 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Twins	73-78	36-40	37-38	36-50	35-27
Guardians	79-71	37-38	42-33	31-31	47-38

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Twins	71-74-6	37-36-3	34-38-3	42-41-3	27-32-3
Guardians	65-79-6	34-38-3	31-41-3	31-30-1	33-47-5

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Twins	66-85	37-39	29-46	41-45	24-38
Guardians	79-71	41-34	38-37	40-22	39-46

date	opponent	score	spread	over/under	moneyline
Sep 16th	NYY	L 9-10	+1.5 W	O 9	NYY +144
Sep 15th	NYY	W 7-0	+1.5 W	U 9	MIN +163
Sep 14th	ARI	L 4-6	-1.5 L	O 9.5	ARI -125
Sep 13th	ARI	L 2-5	-1.5 L	U 8.5	ARI -135
Sep 13th	ARI	W 9-8	-1.5 L	O 8.5	MIN -142

Ben Lively
SP
Lively is out with elbow
Out
John Means
SP
Means is out with elbow
Out

Alan Roden
LF
Roden is out with thumb
Out

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MatchupOverUnder
Guardians 79-71	N/A	N/A
Twins 66-85	N/A	N/A