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Guardians vs. Twins Odds & Betting Predictions - September 21, 2025

Guardians at Twins

6:10 pm • MNNT

Cleveland Guardians

1-2
2
2 - 6

Minnesota Twins

0-0
6
Starting Pitchers
pitcherteameraw-l
Simeon Woods Richardson logoS.Woods RichardsonMinnesota Twins logo4.047-4
Joey Cantillo logoJ.CantilloCleveland Guardians logo3.215-3

Guardians at Twins Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Guardians
1-2
-1.5
-1.5+116
o8.5-117
-143
Twins
0-0
u8.5
+1.5-134
u8.5-105
+121
location pinSunday 6:10 p.m.
September 21, 2025
Target FieldMinneapolis
Guardians vs. Twins Expert Picks
Wags Wins
Wags Wins
Last 30d: 187-205-1 (-30.1u)
Under 8.5+100
1.25u
The Degenerates
The Degenerates
Last 30d: 75-71-1 (-1.6u)
CLE -130
1.3u
Picks Office
Picks Office
Last 30d: 204-169-7 (+22.9u)
CLE -120
2u
Allan Lem
Allan Lem
Last 30d: 160-120-3 (+11.5u)
Under 8.5+100
0.5u
Guardians playing insane baseball now and Simeon Woods Richardson pitching well. Like Guardians ML but getting the u8.5 Total at even odds seems like the better play and just backing both pitching staffs.
Scott Rickenbach
Scott Rickenbach
Last 30d: 127-87-0 (+24.4u)
CLE -132
1u
Charlie Wright
Charlie Wright
Last 30d: 9-8-1 (+3.0u)
S.Woods Richardson o4.5 Ks-134
0.5u
I’m adding a half unit here. The splitter is his best whiff pitch and he’s leaned on it heavily since coming off the IL. The Guardians are an above-average strikeout matchup.
S.Woods Richardson o14.5 Outs-150
1u
After a rocky first start, SWR has been awesome since returning from injury. He’s posted a 2.81 ERA in 3 starts in September. SWR has been spamming a splitter and the results have been tremendous. He struck out a career-high 11 last time out. Cleveland ranks 24th or worse in OPS, wOBA, and wRC+ vs. RHP over the past 30 days. Minnesota used plenty of arms in the doubleheader yesterday, so they could use some length here.

Prop Odds Comparison

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Line Movement Tracker

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Guardians vs. Twins Public Betting Percentages

Away Logo

Guardians

Public

Home Logo

Twins

81%

Bets%

19%

Money%

MLB Public Betting Right Arrow

Betting Trends

  • Twins are 2-3 in their last 5 games.
  • Twins are 3-2 in their last 5 games against the spread
  • Twins are 41-40 in their road games against the spread
  • The totals have gone OVER in 0 of Twins' last 5 games
  • The totals have gone OVER in 39 of Twins' 81 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Twins		78-8437-4441-4036-5140-31
Guardians		86-7639-4247-3433-3651-38

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Twins		73-83-639-39-334-44-342-42-329-39-3
Guardians		69-87-637-41-332-46-334-34-134-50-5

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Twins		70-9238-4332-4941-4628-43
Guardians		88-7445-3643-3844-2543-46

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Sep 20thCLEL 0-8+1.5 LU 8.5CLE -108
Sep 20thCLEL 0-6---
Sep 20thCLEL 2-6+1.5 LO 7.5CLE -108
Sep 17thNYYL 5-10+1.5 LO 9.5NYY +134
Sep 16thNYYL 9-10+1.5 WO 9NYY +144

Guardians vs. Twins Injury Updates

Guardians Injuries

    Twins Injuries

    • Alan Roden
      LF

      Roden is out with thumb

      Out

    See more MLB Injuries Right Arrow
    Guardians vs. Twins Box Score
    Guardians Player Stats
    Projected
    PITCHERPCIPKER
    Joey Cantillo logoLJ.Cantillo, P754.151
    Erik Sabrowski logoLE.Sabrowski, P181.111
    Matt Festa logoRM.Festa, P50.101
    Tim Herrin logoLT.Herrin, P120.212
    Hunter Gaddis logoRH.Gaddis, P90.111
    Zak Kent logoRZ.Kent, P19120
    HITTERSH-ABRHRRBI
    Steven Kwan logo1S.Kwan, LF1-4111
    George Valera logo2G.Valera, DH0-2100
    Jose Ramirez logo3J.Ramirez, 3B1-4000
    Kyle Manzardo logo4K.Manzardo, 1B1-4000
    Bo Naylor logo5B.Naylor, C0-3001
    Gabriel Arias logo6G.Arias, SS0-3000
    Petey Halpin logo6P.Halpin, PH0-1000
    Angel Martinez logo7A.Martinez, CF0-3000
    Daniel Schneemann logo7D.Schneemann, PH0-1000
    CJ Kayfus logo8C.Kayfus, RF0-3000
    Brayan Rocchio logo9B.Rocchio, 2B1-3000
    Twins Player Stats
    Projected
    PITCHERPCIPKER
    Simeon Woods Richardson logoRS.Woods Richardson, P80532
    Kody Funderburk logoLK.Funderburk, P14110
    Pierson Ohl logoRP.Ohl, P9100
    Cole Sands logoRC.Sands, P20110
    Travis Adams logoRT.Adams, P14110
    HITTERSH-ABRHRRBI
    Byron Buxton logo1B.Buxton, CF1-3100
    Kody Clemens logo2K.Clemens, 2B2-4101
    Kody Clemens logo2K.Clemens, 1B2-4101
    Austin Martin logo3A.Martin, LF1-4100
    Trevor Larnach logo4T.Larnach, RF0-3000
    Royce Lewis logo4R.Lewis, PH1-1113
    Royce Lewis logo4R.Lewis, 3B1-1113
    Luke Keaschall logo5L.Keaschall, DH1-4100
    Edouard Julien logo6E.Julien, 1B0-2000
    James Outman logo6J.Outman, RF0-1000
    Brooks Lee logo7B.Lee, SS2-4112
    Jhonny Pereda logo8J.Pereda, C2-4000
    Ryan Fitzgerald logo9R.Fitzgerald, 3B0-4000
    Ryan Fitzgerald logo9R.Fitzgerald, 2B0-4000

    Guardians vs. Twins Odds Comparison

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    Guardians at Twins Team Totals

    MatchupOverUnder
    Guardians
    1-2
    o4.5-113
    u4.5-115
    Twins
    0-0
    o3.5-122
    u3.5-105