Guardians vs. Twins Odds & Betting Predictions - September 21, 2025

Guardians at Twins

6:10 pm • MNNT

Cleveland Guardians

84-72

2 - 6

Minnesota Twins

67-89

pitcher		team	era	w-l
S.Woods Richardson			4.31	7-4
J.Cantillo			3.27	5-3

MatchupOpenSpreadTotalMoneyline
Guardians 84-72	-1.5	-1.5+116	o8.5-117	-143
Twins 67-89	u8.5	+1.5-134	u8.5-105	+121

Sunday 6:10 p.m.

September 21, 2025

Target FieldMinneapolis

Under 8.5+100

1.25u

CLE -130

1.3u

CLE -120

Under 8.5+100

0.5u

Guardians playing insane baseball now and Simeon Woods Richardson pitching well. Like Guardians ML but getting the u8.5 Total at even odds seems like the better play and just backing both pitching staffs.

CLE -132

S.Woods Richardson o4.5 Ks-134

0.5u

I’m adding a half unit here. The splitter is his best whiff pitch and he’s leaned on it heavily since coming off the IL. The Guardians are an above-average strikeout matchup.

S.Woods Richardson o14.5 Outs-150

After a rocky first start, SWR has been awesome since returning from injury. He’s posted a 2.81 ERA in 3 starts in September. SWR has been spamming a splitter and the results have been tremendous. He struck out a career-high 11 last time out. Cleveland ranks 24th or worse in OPS, wOBA, and wRC+ vs. RHP over the past 30 days. Minnesota used plenty of arms in the doubleheader yesterday, so they could use some length here.

No props found

MLB Public Betting

Twins are 0-5 in their last 5 games.
Twins are 1-4 in their last 5 games against the spread
Twins are 37-38 in their road games against the spread
The totals have gone OVER in 3 of Twins' last 5 games
The totals have gone OVER in 39 of Twins' 80 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Twins	73-82	36-44	37-38	36-51	35-29
Guardians	84-71	37-38	47-33	32-31	50-38

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Twins	73-76-6	39-38-3	34-38-3	42-42-3	29-32-3
Guardians	66-83-6	34-38-3	32-45-3	32-30-1	33-50-5

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Twins	66-89	37-43	29-46	41-46	24-40
Guardians	84-71	41-34	43-37	41-22	42-46

date	opponent	score	spread	over/under	moneyline
Sep 20th	CLE	L 0-8	+1.5 L	U 8.5	CLE -108
Sep 20th	CLE	L 0-6	-	-	-
Sep 20th	CLE	L 2-6	+1.5 L	O 7.5	CLE -108
Sep 17th	NYY	L 5-10	+1.5 L	O 9.5	NYY +134
Sep 16th	NYY	L 9-10	+1.5 W	O 9	NYY +144

Ben Lively
SP
Lively is out with elbow
Out
John Means
SP
Means is out with elbow
Out

Alan Roden
LF
Roden is out with thumb
Out

See more MLB Injuries

PITCHER	PC	IP	K	ER
LJ.Cantillo, P	75	4.1	5	1
LE.Sabrowski, P	18	1.1	1	1
RM.Festa, P	5	0.1	0	1
LT.Herrin, P	12	0.2	1	2
RH.Gaddis, P	9	0.1	1	1
RZ.Kent, P	19	1	2	0

HITTERS	H-AB	R	HR	RBI
1S.Kwan, LF	1-4	1	1	1
2G.Valera, DH	0-2	1	0	0
3J.Ramirez, 3B	1-4	0	0	0
4K.Manzardo, 1B	1-4	0	0	0
5B.Naylor, C	0-3	0	0	1
6G.Arias, SS	0-3	0	0	0
6P.Halpin, PH	0-1	0	0	0
7A.Martinez, CF	0-3	0	0	0
7D.Schneemann, PH	0-1	0	0	0
8C.Kayfus, RF	0-3	0	0	0
9B.Rocchio, 2B	1-3	0	0	0

PITCHER	PC	IP	K	ER
RS.Woods Richardson, P	80	5	3	2
LK.Funderburk, P	14	1	1	0
RP.Ohl, P	9	1	0	0
RC.Sands, P	20	1	1	0
RT.Adams, P	14	1	1	0

HITTERS	H-AB	R	HR	RBI
1B.Buxton, CF	1-3	1	0	0
2K.Clemens, 2B	2-4	1	0	1
2K.Clemens, 1B	2-4	1	0	1
3A.Martin, LF	1-4	1	0	0
4T.Larnach, RF	0-3	0	0	0
4R.Lewis, PH	1-1	1	1	3
4R.Lewis, 3B	1-1	1	1	3
5L.Keaschall, DH	1-4	1	0	0
6E.Julien, 1B	0-2	0	0	0
6J.Outman, RF	0-1	0	0	0
7B.Lee, SS	2-4	1	1	2
8J.Pereda, C	2-4	0	0	0
9R.Fitzgerald, 3B	0-4	0	0	0
9R.Fitzgerald, 2B	0-4	0	0	0