Twins vs. Guardians Odds & Betting Predictions - July 21, 2026

Twins at Guardians

10:40 pm • MNNT
2 - 5
Starting Pitchers
pitcherteameraw-l
Parker Messick logoP.MessickCleveland Guardians logo2.688-5
Kendry Rojas logoK.RojasMinnesota Twins logo3.321-1

Twins at Guardians Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Twins
49-53
+1.5
+1.5-161
o8-103
+132
Guardians
54-48
u8.5
-1.5+134
u8-116
-157
location pinTuesday 10:40 p.m.
July 21, 2026
Progressive FieldCleveland
Twins vs. Guardians Expert Picks
OldSchool0909
Last 30d: 32-36-0 (+3.5u)
MIN +130
1u
Adam Kaufman
Adam Kaufman
Last 30d: 124-108-3 (+10.4u)
CLE -148
1u
Frank Ammirante
Frank Ammirante
Last 30d: 342-377-7 (-32.9u)
CLE -152
1u
P.Messick o4.5 Ks-164
1u

Twins vs. Guardians Previews & Analysis

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Prop Odds Comparison

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Line Movement Tracker

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Twins vs. Guardians Public Betting Percentages

Away Logo

Twins

Public

14%

Bets%

86%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Guardians
53-4926-2527-2424-3129-15
Twins
52-5026-2526-2513-1938-30

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Guardians
48-5426-2522-2928-2719-25
Twins
56-40-624-23-432-17-217-14-138-25-5

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Guardians
54-4827-2427-2430-2524-20
Twins
49-5326-2523-2817-1531-37

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Jul 20thMINW 13-4+1.5 WO 7.5CLE +111
Jul 19thPITL 1-7+1.5 LO 7PIT -116
Jul 18thPITW 5-3+1.5 WU 8.5CLE -110
Jul 18thPITL 1-7-1.5 LO 7.5PIT -131
Jul 12th@MIAW 5-2-1.5 WU 7.5CLE -114

Guardians vs. Twins Injury Updates

Guardians Injuries

    Twins Injuries

    • Pablo Lopez
      SP

      Lopez is out with elbow

      Out

    • David Festa
      SP

      Festa is out with shoulder

      Out

    • Travis Adams
      SP

      Adams is out with triceps

      Out

    Twins vs. Guardians Box Score
    Twins Player Stats
    Projected
    PITCHERPCIPKER
    Kendry Rojas logoLK.Rojas, P472.122
    Mike Paredes logoRM.Paredes, P49302
    Taylor Rogers logoLT.Rogers, P281.101
    Jack Anderson logoRJ.Anderson, P81.110
    HITTERSH-ABRHRRBI
    Austin Martin logo1A.Martin, LF0-3000
    Trevor Larnach logo1T.Larnach, PH1-1000
    Trevor Larnach logo1T.Larnach, LF1-1000
    Byron Buxton logo2B.Buxton, CF1-4000
    Ryan Jeffers logo3R.Jeffers, C1-4111
    Josh Bell logo4J.Bell, DH1-4100
    Royce Lewis logo5R.Lewis, 3B0-3000
    Victor Caratini logo6V.Caratini, 1B0-4000
    Kody Clemens logo7K.Clemens, 2B2-4000
    Luke Keaschall logo8L.Keaschall, RF0-4000
    Ryan Kreidler logo9R.Kreidler, SS0-3000
    Guardians Player Stats
    Projected
    PITCHERPCIPKER
    Parker Messick logoLP.Messick, P885.261
    Colin Holderman logoRC.Holderman, P80.100
    Shawn Armstrong logoRS.Armstrong, P170.210
    Hunter Gaddis logoRH.Gaddis, P171.110
    Cade Smith logoRC.Smith, P11110
    HITTERSH-ABRHRRBI
    Steven Kwan logo1S.Kwan, LF1-3101
    Brayan Rocchio logo2B.Rocchio, SS2-4001
    Chase DeLauter logo3C.DeLauter, DH2-4000
    Rhys Hoskins logo4R.Hoskins, 1B0-2000
    Kyle Manzardo logo4K.Manzardo, PH0-2100
    Kyle Manzardo logo4K.Manzardo, 1B0-2100
    David Fry logo5D.Fry, RF0-2000
    Kahlil Watson logo5K.Watson, PH1-2100
    Kahlil Watson logo5K.Watson, RF1-2100
    Travis Bazzana logo6T.Bazzana, 2B1-2101
    Gabriel Arias logo7G.Arias, 3B2-4000
    Austin Hedges logo8A.Hedges, C0-2101
    Petey Halpin logo9P.Halpin, CF0-2001

    Twins vs. Guardians Odds Comparison

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    Twins at Guardians Team Totals

    MatchupOverUnder
    Twins
    49-53
    N/A
    N/A
    Guardians
    54-48
    N/A
    N/A