Twins vs. Guardians Odds & Betting Predictions - July 21, 2026
Twins at Guardians
10:40 pm • MNNTStarting Pitchers
| pitcher | team | era | w-l | |
|---|---|---|---|---|
![]() | 2.68 | 8-5 | ||
![]() | 3.32 | 1-1 |
Twins at Guardians Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
Twins 49-53 | +1.5 | +1.5-161 | o8-103 | +132 |
Guardians 54-48 | u8.5 | -1.5+134 | u8-116 | -157 |

Progressive FieldCleveland
Twins vs. Guardians Expert Picks
OldSchool0909
Last 30d: 32-36-0 (+3.5u)
MIN +130
1u
Brian Bitler
Last 30d: 47-58-1 (-31.4u)
MIN +133
3u
Adam Kaufman
Last 30d: 124-108-3 (+10.4u)
CLE -148
1u
Frank Ammirante
Last 30d: 342-377-7 (-32.9u)
CLE -152
1u
P.Messick o4.5 Ks-164
1u
Twins vs. Guardians Previews & Analysis
Prop Odds Comparison
Line Movement Tracker
Twins vs. Guardians Public Betting Percentages
Betting Trends
- Guardians are 3-2 in their last 5 games.
- Guardians are 3-2 in their last 5 games against the spread
- Guardians are 27-24 in their road games against the spread
- The totals have gone OVER in 3 of Guardians' last 5 games
- The totals have gone OVER in 26 of Guardians' 51 last games at home
Matchup History
Against the Spread (ATS) History
Over/Under History
Last 5 Matchups
Guardians vs. Twins Injury Updates

Guardians Injuries

Twins Injuries
- Pablo LopezSP
Lopez is out with elbow
Out
- David FestaSP
Festa is out with shoulder
Out
- Travis AdamsSP
Adams is out with triceps
Out
Twins vs. Guardians Box Score
Twins Player Stats| PITCHER | PC | IP | K | ER | |
|---|---|---|---|---|---|
![]() | 47 | 2.1 | 2 | 2 | |
![]() | 49 | 3 | 0 | 2 | |
![]() | 28 | 1.1 | 0 | 1 | |
![]() | 8 | 1.1 | 1 | 0 |
| HITTERS | H-AB | R | HR | RBI |
|---|---|---|---|---|
![]() | 0-3 | 0 | 0 | 0 |
![]() | 1-1 | 0 | 0 | 0 |
![]() | 1-1 | 0 | 0 | 0 |
![]() | 1-4 | 0 | 0 | 0 |
![]() | 1-4 | 1 | 1 | 1 |
![]() | 1-4 | 1 | 0 | 0 |
![]() | 0-3 | 0 | 0 | 0 |
![]() | 0-4 | 0 | 0 | 0 |
![]() | 2-4 | 0 | 0 | 0 |
![]() | 0-4 | 0 | 0 | 0 |
![]() | 0-3 | 0 | 0 | 0 |
Guardians Player Stats| PITCHER | PC | IP | K | ER | |
|---|---|---|---|---|---|
![]() | 88 | 5.2 | 6 | 1 | |
![]() | 8 | 0.1 | 0 | 0 | |
![]() | 17 | 0.2 | 1 | 0 | |
![]() | 17 | 1.1 | 1 | 0 | |
![]() | 11 | 1 | 1 | 0 |
| HITTERS | H-AB | R | HR | RBI |
|---|---|---|---|---|
![]() | 1-3 | 1 | 0 | 1 |
![]() | 2-4 | 0 | 0 | 1 |
![]() | 2-4 | 0 | 0 | 0 |
![]() | 0-2 | 0 | 0 | 0 |
![]() | 0-2 | 1 | 0 | 0 |
![]() | 0-2 | 1 | 0 | 0 |
![]() | 0-2 | 0 | 0 | 0 |
![]() | 1-2 | 1 | 0 | 0 |
![]() | 1-2 | 1 | 0 | 0 |
![]() | 1-2 | 1 | 0 | 1 |
![]() | 2-4 | 0 | 0 | 0 |
![]() | 0-2 | 1 | 0 | 1 |
![]() | 0-2 | 0 | 0 | 1 |
Twins vs. Guardians Odds Comparison
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Twins at Guardians Team Totals
MatchupOverUnder | ||
|---|---|---|
Twins 49-53 | N/A | N/A |
Guardians 54-48 | N/A | N/A |
































