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Diamondbacks vs Padres Prediction, Pick, Odds for Friday, September 26

Diamondbacks vs Padres Prediction, Pick, Odds for Friday, September 26 article feature image
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Photo by Robert Edwards-Imagn Images. Pictured: Zac Gallen

The San Diego Padres host the Arizona Diamondbacks on September 26, 2025. First pitch from PETCO Park is scheduled for 9:40 p.m. EDT; the game will be broadcast on SDPA.

Arizona's Zac Gallen against San Diego's Yu Darvish is the pitching matchup tonight. The Diamondbacks are still alive in the playoff race, but they could get eliminated soon, while the Padres are pretty locked in to begin the playoffs in Chicago against the Cubs.

Find my MLB betting preview and Diamondbacks vs Padres prediction below, as well as probable pitchers, betting trends, injury reports and more.

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My Diamondbacks vs Padres Prediction

  • Diamondbacks vs Padres pick: Zac Gallen Under 17.5 Outs (+132)

My Diamondbacks vs Padres best bet is Under 17.5 outs for Zac Gallen tonight. Make sure to find the best odds by checking our live MLB odds page.


Diamondbacks vs Padres Odds

Diamondbacks Logo
Friday, Sep 26
9:40 p.m. ET
SDPA
Padres Logo
Diamondbacks Odds
SpreadTotalMoneyline
+1.5
-180
7.5
-115o / -105u
+120
Padres Odds
SpreadTotalMoneyline
-1.5
+150
7.5
-115o / -105u
-140
Odds via bet365. Get up-to-the-minute MLB odds here.
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Diamondbacks vs Padres Projected Starting Pitchers

RHP Zac Gallen (ARI)StatRHP Yu Darvish (SD)
13-14W-L4-5
1.1fWAR (FanGraphs)0.5
4.70 / 4.32ERA / xERA5.51 / 3.29
4.46 / 4.06FIP / xFIP4.59 / 4.05
1.24WHIP1.15
13.8K-BB%17.0
43.6GB%41.2
93Stuff+100
105Location+99

Derek Carty’s Diamondbacks vs Padres Preview, Prediction

I like Zac Gallen's pitching outs prop for tonight. The line opened at Under 18.5, but it flipped at 17.5 at plus money. So, if you're getting 17.5 at +130 or even +120, that will also do well.

The BAT X is projecting about 16 outs in this game for the Diamondbacks starter.

It will be Gallen's last start of the year. Guys tend to get less of a leash as we go deeper into the season, and in his final outing, he will not be throwing the same amount of pitches or the same amount of innings as he does in July. It just doesn't happen.

Gallen will be facing a good Padres lineup. There are several ways he can get under the line, whether it's his team deciding he will not go long into the seventh inning, or he gets hit around a little bit.

He's not efficient, so I like the Gallen under as a play for this game.

Pick: Zac Gallen Under 17.5 Outs (+132, bet365)


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